RRC ID 46884
Author Mori T, Nakamura Y, Kato J, Sugita K, Murata M, Kamei K, Okamoto S.
Title Fungemia due to Rhodotorula mucilaginosa after allogeneic hematopoietic stem cell transplantation.
Journal Transpl Infect Dis
Abstract Rhodotorula species have been increasingly recognized as emerging pathogens, particularly in immunocompromised patients. We herein report on a patient with myelodysplastic syndrome who developed fungemia due to Rhodotorula mucilaginosa after allogeneic hematopoietic stem cell transplantation (HSCT) from an unrelated donor. He developed severe acute graft-versus-host disease requiring high-dose steroids, and had serially been administered fluconazole and micafungin for the prophylaxis of fungal infection. Although several cases of Rhodotorula infection after HSCT have been reported, all of them were recipients of autologous HSCT, not allogeneic HSCT. A review of all the reported cases of Rhodotorula infection after HSCT revealed that all patients had received fluconazole or echinocandins before the onset of infection. The findings suggest that Rhodotorula species could be causative yeasts, particularly in patients receiving fluconazole or echinocandins, both of which are inactive against the species.
Volume 14(1)
Pages 91-4
Published 2012-2-1
DOI 10.1111/j.1399-3062.2011.00647.x
PMID 21535337
MeSH Amphotericin B / therapeutic use Antifungal Agents / therapeutic use Fungemia / drug therapy Fungemia / microbiology* Graft vs Host Disease / etiology Hematopoietic Stem Cell Transplantation / adverse effects* Humans Male Middle Aged Mycoses / drug therapy Mycoses / microbiology* Myelodysplastic Syndromes / therapy Rhodotorula / classification Rhodotorula / genetics Rhodotorula / isolation & purification* Transplantation, Homologous / adverse effects Unrelated Donors
IF 2.071
Times Cited 18
Pathogenic microorganisms