論文 - 詳細
| RRC ID | 46896 |
|---|---|
| 著者 | Toyotome T, Yamaguchi M, Iwasaki A, Watanabe A, Taguchi H, Qin L, Watanabe H, Kamei K. |
| タイトル | Fetuin A, a serum component, promotes growth and biofilm formation by Aspergillus fumigatus. |
| ジャーナル | Int J Med Microbiol |
| Abstract |
Aspergillus fumigatus is an all-important pathogenic fungus and is known for its angiotropism. When it invades human organs, A. fumigatus makes direct contact with blood and its components by causing inflammation and invading vascular structures. To learn the effect of its contact with blood on the development of infection, we examined the effect of serum on A. fumigatus growth. In Dulbecco's modified Eagle's medium containing 10% fetal bovine serum, hyphal tip growth was accelerated, forming a thickened and well-networked biofilm associated with extracellular matrix, and fetuin A was identified as the active component in the serum that accelerates fungal growth leading to formation of a community. These results suggest that fetuin A is a novel accelerator of the growth of A. fumigatus and that it participates in the formation of thick biofilm. |
| 巻・号 | 302(2) |
| ページ | 108-16 |
| 公開日 | 2012-3-1 |
| DOI | 10.1016/j.ijmm.2011.12.001 |
| PII | S1438-4221(12)00002-1 |
| PMID | 22293034 |
| MeSH | Animals Aspergillus fumigatus / drug effects* Aspergillus fumigatus / physiology* Aspergillus fumigatus / ultrastructure Biofilms / drug effects* Biofilms / growth & development* Cattle Humans Hyphae / metabolism Hyphae / ultrastructure Polysaccharides / metabolism alpha-2-HS-Glycoprotein / metabolism alpha-2-HS-Glycoprotein / pharmacology* |
| IF | 3.113 |
| 引用数 | 12 |
| WOS 分野 | MICROBIOLOGY VIROLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 病原微生物 | |