RRC ID 46933
Author Saijo S, Iwakura Y.
Title Dectin-1 and Dectin-2 in innate immunity against fungi.
Journal Int Immunol
Abstract Dectin-1 and Dectin-2 are type II transmembrane proteins of the C-type lectin family with single carbohydrate recognition domains (CRDs) in their extracellular region. They are expressed mainly in dendritic cells and macrophages. Dectin-1 recognizes β-glucans with its CRD and transduces signals through its immunoreceptor tyrosine-based activation motif (ITAM)-like motif in the cytoplasmic domain, whereas Dectin-2 recognizes α-mannans and transduces its signal through association with the ITAM-containing Fc receptor γ chain. Upon ligand binding, spleen tyrosine kinase is recruited to the ITAM and activates the caspase recruitment domain family member 9 (CARD9)-nuclear factor-κB axis, resulting in the activation of various genes including those encoding pro-inflammatory cytokines. Both β-glucans and α-mannans are major cell wall components of fungi including Candida albicans and Pneumocystis carinii. Recently, it was reported that Dectin-1 is important in protection against P. carinii by inducing reactive oxygen species, whereas both Dectin-1 and Dectin-2 play important roles in defense against C. albicans by preferentially inducing T(h)17 cell differentiation. In this review, we briefly revisit the structures, ligands, signal transduction and functional roles of Dectin-1 and Dectin-2 in host defense against fungal infection.
Volume 23(8)
Pages 467-72
Published 2011-8-1
DOI 10.1093/intimm/dxr046
PII dxr046
PMID 21677049
MeSH Animals Fungi / immunology* Humans Immunity, Innate / immunology* Lectins, C-Type / chemistry Lectins, C-Type / metabolism Lectins, C-Type / physiology* Ligands Membrane Proteins / chemistry Membrane Proteins / metabolism Membrane Proteins / physiology* Mycoses / immunology* Nerve Tissue Proteins / chemistry Nerve Tissue Proteins / metabolism Nerve Tissue Proteins / physiology* Signal Transduction / immunology
IF 3.519
Times Cited 104
Pathogenic microorganisms ?