論文 - 詳細
| RRC ID | 46933 |
|---|---|
| 著者 | Saijo S, Iwakura Y. |
| タイトル | Dectin-1 and Dectin-2 in innate immunity against fungi. |
| ジャーナル | Int Immunol |
| Abstract |
Dectin-1 and Dectin-2 are type II transmembrane proteins of the C-type lectin family with single carbohydrate recognition domains (CRDs) in their extracellular region. They are expressed mainly in dendritic cells and macrophages. Dectin-1 recognizes β-glucans with its CRD and transduces signals through its immunoreceptor tyrosine-based activation motif (ITAM)-like motif in the cytoplasmic domain, whereas Dectin-2 recognizes α-mannans and transduces its signal through association with the ITAM-containing Fc receptor γ chain. Upon ligand binding, spleen tyrosine kinase is recruited to the ITAM and activates the caspase recruitment domain family member 9 (CARD9)-nuclear factor-κB axis, resulting in the activation of various genes including those encoding pro-inflammatory cytokines. Both β-glucans and α-mannans are major cell wall components of fungi including Candida albicans and Pneumocystis carinii. Recently, it was reported that Dectin-1 is important in protection against P. carinii by inducing reactive oxygen species, whereas both Dectin-1 and Dectin-2 play important roles in defense against C. albicans by preferentially inducing T(h)17 cell differentiation. In this review, we briefly revisit the structures, ligands, signal transduction and functional roles of Dectin-1 and Dectin-2 in host defense against fungal infection. |
| 巻・号 | 23(8) |
| ページ | 467-72 |
| 公開日 | 2011-8-1 |
| DOI | 10.1093/intimm/dxr046 |
| PII | dxr046 |
| PMID | 21677049 |
| MeSH | Animals Fungi / immunology* Humans Immunity, Innate / immunology* Lectins, C-Type / chemistry Lectins, C-Type / metabolism Lectins, C-Type / physiology* Ligands Membrane Proteins / chemistry Membrane Proteins / metabolism Membrane Proteins / physiology* Mycoses / immunology* Nerve Tissue Proteins / chemistry Nerve Tissue Proteins / metabolism Nerve Tissue Proteins / physiology* Signal Transduction / immunology |
| IF | 3.519 |
| 引用数 | 104 |
| WOS 分野 | IMMUNOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 13 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 3.0 |
| リソース情報 | |
| 病原微生物 | |