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RRC ID 46940
Author Tanaka N, Mamemura T, Shibazaki A, Gonoi T, Kobayashi J.
Title Yojironins E-I, prenylated acylphloroglucinols from Hypericum yojiroanum.
Journal Bioorg Med Chem Lett
Abstract Five new prenylated acylphloroglucinols, yojironins E-Ι (1-5), were isolated from the whole plants of Hypericum yojiroanum. Their structures were elucidated by spectroscopic data. Yojironin E (1) exhibited antimicrobial activity against Aspergillus niger, Candida albicans, Cryptococcus neoformans, and Trichophyton mentagrophytes.
Volume 21(18)
Pages 5393-7
Published 2011-9-15
DOI 10.1016/j.bmcl.2011.07.004
PII S0960-894X(11)00922-X
PMID 21802287
MeSH Animals Antifungal Agents / chemistry Antifungal Agents / isolation & purification Antifungal Agents / pharmacology* Antineoplastic Agents / chemistry Antineoplastic Agents / isolation & purification Antineoplastic Agents / pharmacology Aspergillus niger / drug effects Candida albicans / drug effects Cell Line, Tumor Cryptococcus neoformans / drug effects Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Humans Hypericum / chemistry* Magnetic Resonance Spectroscopy Mice Microbial Sensitivity Tests Models, Molecular Molecular Conformation Phloroglucinol / analogs & derivatives* Phloroglucinol / chemistry Phloroglucinol / pharmacology* Stereoisomerism Structure-Activity Relationship Trichophyton / drug effects
IF 2.572
Times Cited 6
WOS Category CHEMISTRY, MEDICINAL CHEMISTRY, ORGANIC
Resource
Pathogenic microorganisms NA