RRC ID 46971
Author Ohji G, Kikuchi K, Inoue K, Imoto K, Yamamoto S, Hosokawa N, Kamei K, Iwata K.
Title Progressive disseminated histoplasmosis in an immunocompetent patient as an underrecognized imported mycosis in Japan.
Journal J Infect Chemother
Abstract Histoplasmosis caused by Histoplasma capsulatum is found worldwide. Japan is known to be non-endemic area. Progressive disseminated histoplasmosis (PDH) is a severe form of histoplasmosis. We report a case of PDH in a 54-year-old male who was not immunocompromised. His last travel history to an endemic region was 2 years before onset. He was diagnosed as histoplasmosis by 18S rRNA-PCR from serum and ascites and immunodiffusion test. We treated him with parental liposomal amphotericin B for 2 weeks then changed to oral itraconazole, which was continued for 6 months. Rigorous work up, including HIV status, lymphocyte counts, and adrenal function did not reveal any evidence of immunosuppression of the patient. Our case suggests that PDH can occur in immunocompetent patients as previously described, and must be included in the differential diagnoses if presentation is consistent. In addition, the skills of travel history taking are emphasized.
Volume 16(6)
Pages 443-5
Published 2010-12-1
DOI 10.1007/s10156-010-0073-5
PII S1341-321X(10)70569-9
PMID 20549287
MeSH Amphotericin B / therapeutic use Antifungal Agents / therapeutic use Histoplasma / genetics Histoplasma / isolation & purification* Histoplasmosis / diagnosis* Histoplasmosis / drug therapy Histoplasmosis / microbiology Humans Immunocompetence* Itraconazole / therapeutic use Japan Male Middle Aged Polymerase Chain Reaction / methods RNA, Ribosomal, 18S / genetics Travel*
IF 1.722
Times Cited 1
Pathogenic microorganisms NA