Reference - Detail
| RRC ID | 47001 |
|---|---|
| Author | Araki A, Kubota T, Aoyama K, Mikami Y, Fromont J, Kobayashi J. |
| Title | Nagelamides Q and R, novel dimeric bromopyrrole alkaloids from sponges Agelas sp. |
| Journal | Org Lett |
| Abstract |
Two new dimeric bromopyrrole alkaloids, nagelamides Q (1) and R (2), have been isolated from Okinawan marine sponges of the genus Agelas (SS-1134 and SS-956, respectively), and the structures and stereochemistry were elucidated from spectroscopic data. Nagelamide Q (1) is a rare dimeric bromopyrrole alkaloid possessing a pyrrolidine ring, while nagelamide R (2) is the first bromopyrrole alkaloid having an oxazoline ring. Nagelamides Q (1) and R (2) showed antimicrobial activity. |
| Volume | 11(8) |
| Pages | 1785-8 |
| Published | 2009-4-16 |
| DOI | 10.1021/ol900328c |
| PMID | 19296638 |
| MeSH | Agelas / chemistry* Alkaloids / chemistry Alkaloids / isolation & purification* Alkaloids / pharmacology Animals Aspergillus niger / drug effects Bacillus subtilis / drug effects Candida albicans / drug effects Cryptococcus neoformans / drug effects Escherichia coli / drug effects Imidazoles / chemistry Imidazoles / isolation & purification* Imidazoles / pharmacology Microbial Sensitivity Tests Micrococcus luteus / drug effects Molecular Structure Nuclear Magnetic Resonance, Biomolecular Pyrroles / chemistry Pyrroles / isolation & purification* Pyrroles / pharmacology Staphylococcus aureus / drug effects Trichophyton / drug effects |
| IF | 6.091 |
| Times Cited | 34 |
| WOS Category | CHEMISTRY, ORGANIC |
| Resource | |
| Pathogenic microorganisms | NA |