論文 - 詳細
| RRC ID | 47005 |
|---|---|
| 著者 | Ito E, Yasumoto T. |
| タイトル | Toxicological studies on palytoxin and ostreocin-D administered to mice by three different routes. |
| ジャーナル | Toxicon |
| Abstract |
Palytoxin (PLT) first isolated from zoanthids is extremely lethal to animals by intraperitoneal or intravenous administration but shows little toxicity by gavage dosing in contradiction to the occurrence of fatal poisoning due to PLT-containing seafood. In order to fully elucidate its potential risks to human we evaluated the toxicological effects via three ways of dosing: gavage, intra-tracheal administration (IT) and sublingual administration. A new analog, 42-hydroxy-3,26-didemethyl-19,44-dideoxypalytoxin isolated from the dinoflagellate Ostreopsis siamensis and named ostreocin-D (OSD), was also used for comparison, additionally conducted by i.p. By gavage dosing, both toxins did not produce death in mice at the maximum dosage of 200 microg/kg of PLT and 300 microg/kg of OSD. Addition of dietary lipid components to PLT solutions for gavage or use of ulcerated mice did not alter the results, indicating no enhancement of PLT absorption. The two toxins were most toxic by the IT route, causing bleeding and alveolar destruction in the lung and resultant death at 2 microg/kg of PLT, and 11 microg/kg of OSD. Both toxins also induced organ injuries after 24h when dosed by sublingual administration at about 200 microg/kg. The injuries became fatal when PLT was dosed 2 or 3 times. The results pointed to the necessity of taking multiple approaches to assess the potential health risks due to PLT and its analogs in food and environments. |
| 巻・号 | 54(3) |
| ページ | 244-51 |
| 公開日 | 2009-9-1 |
| DOI | 10.1016/j.toxicon.2009.04.009 |
| PII | S0041-0101(09)00216-5 |
| PMID | 19376151 |
| MeSH | Acrylamides / administration & dosage Acrylamides / toxicity* Animals Bridged Bicyclo Compounds, Heterocyclic / administration & dosage Bridged Bicyclo Compounds, Heterocyclic / toxicity* Cnidarian Venoms Dose-Response Relationship, Drug Drug Administration Routes Intestine, Small / drug effects Intestine, Small / pathology Kidney Cortex / drug effects Kidney Cortex / pathology Lung / drug effects Lung / pathology Male Mice Mice, Inbred ICR Pyrans / administration & dosage Pyrans / toxicity* Rats Rats, Wistar Stomach / drug effects Stomach / pathology |
| IF | 2.201 |
| 引用数 | 43 |
| WOS 分野 | PHARMACOLOGY & PHARMACY TOXICOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 8 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 病原微生物 | NA |