| RRC ID |
47009
|
| Author |
Mukai A, Fukai T, Hoshino Y, Yazawa K, Harada K, Mikami Y.
|
| Title |
Nocardithiocin, a novel thiopeptide antibiotic, produced by pathogenic Nocardia pseudobrasiliensis IFM 0757.
|
| Journal |
J Antibiot (Tokyo)
|
| Abstract |
Nocardithiocin is a novel thiopeptide compound produced by the pathogenic Nocardia pseudobrasiliensis strain IFM 0757. It shows a strong activity against acid-fast bacilli such as the Mycobacterium and Gordonia species. Nocardithiocin was highly active against rifampicin-resistant as well as -sensitive Mycobacterium tuberculosis strains, and most of the resistant strains were inhibited at concentrations ranging from 0.025 to 1.56 microg ml(-1). The structure of the thiopeptide antibiotic containing thiazole, natural and unnatural amino acids was elucidated by MS and NMR spectral analyses.
|
| Volume |
62(11)
|
| Pages |
613-9
|
| Published |
2009-11-1
|
| DOI |
10.1038/ja.2009.90
|
| PII |
ja200990
|
| PMID |
19745839
|
| MeSH |
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / isolation & purification*
Anti-Bacterial Agents / pharmacology
Fermentation
Magnetic Resonance Spectroscopy
Nocardia / metabolism*
Peptides, Cyclic / chemistry
Peptides, Cyclic / isolation & purification*
Peptides, Cyclic / pharmacology
Stereoisomerism
Thiazoles / chemistry
Thiazoles / isolation & purification*
Thiazoles / pharmacology
|
| IF |
2.668
|
| Times Cited |
35
|
|
WOS Category
|
PHARMACOLOGY & PHARMACY
BIOTECHNOLOGY & APPLIED MICROBIOLOGY
MICROBIOLOGY
IMMUNOLOGY
|
| Resource |
| Pathogenic microorganisms |
IFM 0757
IFM 2057 |
