RRC ID 47013
Author Oarada M, Igarashi M, Tsuzuki T, Kurita N, Gonoi T, Nikawa T, Hirasaka K, Miyazawa T, Nakagawa K, Kamei K.
Title Effect of dietary oils on host resistance to fungal infection in psychologically stressed mice.
Journal Biosci. Biotechnol. Biochem.
Abstract Psychological stress can modulate host defense against invading pathogens. In this study, we investigated the effect of dietary oils on social isolation stress-induced modulation of host resistance to Paracoccidioides brasiliensis. In olive oil-fed mice, 3 weeks of isolation stress resulted in temporarily delayed clearance of this fungus in the liver compared with group-housed mice. By contrast, in soybean oil-fed mice, isolation stress had no significant effect on antifungal activity. The olive oil-fed mice showed greater liver interferon (IFN)-gamma and interleukin (IL)-6 production in response to infection as compared with the soybean oil-fed mice. In the olive oil-fed mice, isolation stress led to greater infection-induced IFN-gamma production in the liver compared with the group-housed animals. These results indicate that the modulatory effects of psychological stress on host resistance to P. brasiliensis can vary depending on dietary fatty acid composition.
Volume 73(9)
Pages 1994-8
Published 2009-9
DOI 10.1271/bbb.90184
PII JST.JSTAGE/bbb/90184
PMID 19734677
MeSH Animals Dietary Fats, Unsaturated / pharmacology* Female Interferon-gamma / biosynthesis Interleukin-6 / biosynthesis Liver / drug effects* Liver / metabolism Mice Mice, Inbred BALB C Mycoses / immunology* Organ Size / drug effects Social Isolation Spleen / drug effects Stress, Psychological*
IF 1.255
Times Cited 4
WOS Category FOOD SCIENCE & TECHNOLOGY CHEMISTRY, APPLIED BIOTECHNOLOGY & APPLIED MICROBIOLOGY BIOCHEMISTRY & MOLECULAR BIOLOGY
Resource
Pathogenic microorganisms ?