| RRC ID |
47013
|
| 著者 |
Oarada M, Igarashi M, Tsuzuki T, Kurita N, Gonoi T, Nikawa T, Hirasaka K, Miyazawa T, Nakagawa K, Kamei K.
|
| タイトル |
Effect of dietary oils on host resistance to fungal infection in psychologically stressed mice.
|
| ジャーナル |
Biosci Biotechnol Biochem
|
| Abstract |
Psychological stress can modulate host defense against invading pathogens. In this study, we investigated the effect of dietary oils on social isolation stress-induced modulation of host resistance to Paracoccidioides brasiliensis. In olive oil-fed mice, 3 weeks of isolation stress resulted in temporarily delayed clearance of this fungus in the liver compared with group-housed mice. By contrast, in soybean oil-fed mice, isolation stress had no significant effect on antifungal activity. The olive oil-fed mice showed greater liver interferon (IFN)-gamma and interleukin (IL)-6 production in response to infection as compared with the soybean oil-fed mice. In the olive oil-fed mice, isolation stress led to greater infection-induced IFN-gamma production in the liver compared with the group-housed animals. These results indicate that the modulatory effects of psychological stress on host resistance to P. brasiliensis can vary depending on dietary fatty acid composition.
|
| 巻・号 |
73(9)
|
| ページ |
1994-8
|
| 公開日 |
2009-9-1
|
| DOI |
10.1271/bbb.90184
|
| PII |
JST.JSTAGE/bbb/90184
|
| PMID |
19734677
|
| MeSH |
Animals
Dietary Fats, Unsaturated / pharmacology*
Female
Interferon-gamma / biosynthesis
Interleukin-6 / biosynthesis
Liver / drug effects*
Liver / metabolism
Mice
Mice, Inbred BALB C
Mycoses / immunology*
Organ Size / drug effects
Social Isolation
Spleen / drug effects
Stress, Psychological*
|
| IF |
1.516
|
| 引用数 |
4
|
|
WOS 分野
|
FOOD SCIENCE & TECHNOLOGY
CHEMISTRY, APPLIED
BIOTECHNOLOGY & APPLIED MICROBIOLOGY
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| リソース情報 |
| 病原微生物 |
|
