| RRC ID |
47017
|
| 著者 |
Sugino K, Gocho K, Ota H, Kobayashi M, Sano G, Isobe K, Takai Y, Izumi H, Kuraishi Y, Shibuya K, Homma S.
|
| タイトル |
Miliary tuberculosis associated with chronic neutrophilic leukemia.
|
| ジャーナル |
Intern Med
|
| Abstract |
We report a case of miliary tuberculosis associated with chronic neutrophilic leukemia (CNL). A 70-year-old woman was referred to our hospital complaining of a 1-month history of persistent fever and anorexia. Chest and abdominal computed tomography images revealed diffuse small nodular lesions in the bilateral lung fields and extreme splenomegaly. Sputum cultures isolated Mycobacterium tuberculosis. After anti-tuberculous therapy for 1 year, the patient underwent splenectomy for massive splenomegaly and progressive leukocytosis. The presence of the homozygous JAK2 V617F tyrosine kinase mutation was also demonstrated in the peripheral blood. She was finally diagnosed as having miliary tuberculosis associated with CNL based on the histopathological examination of spleen. The patient was treated with a daily dose of 500 mg of hydroxyurea. As a result, 18 months after the splenectomy, her leukocyte count was decreased and her clinical condition was markedly improved; there was no relapse of the CNL.
|
| 巻・号 |
48(15)
|
| ページ |
1283-7
|
| 公開日 |
2009-1-1
|
| DOI |
10.2169/internalmedicine.48.2080
|
| PII |
JST.JSTAGE/internalmedicine/48.2080
|
| PMID |
19652431
|
| MeSH |
Aged
Bone Marrow / pathology
Female
Homozygote
Humans
Janus Kinase 2 / genetics
Leukemia, Neutrophilic, Chronic / complications*
Leukemia, Neutrophilic, Chronic / diagnosis*
Leukemia, Neutrophilic, Chronic / enzymology
Leukemia, Neutrophilic, Chronic / genetics
Mutation, Missense
Spleen / pathology
Tomography, X-Ray Computed
Tuberculosis, Miliary / complications*
Tuberculosis, Miliary / diagnosis*
Tuberculosis, Splenic / complications
Tuberculosis, Splenic / diagnosis
|
| IF |
1.005
|
| 引用数 |
6
|
|
WOS 分野
|
HEMATOLOGY
|
| リソース情報 |
| 病原微生物 |
|
