| RRC ID |
47047
|
| Author |
Tanaka N, Kubota T, Ishiyama H, Araki A, Kashiwada Y, Takaishi Y, Mikami Y, Kobayashi J.
|
| Title |
Petiolins A-C, phloroglucinol derivatives from Hypericum pseudopetiolatum var. kiusianum.
|
| Journal |
Bioorg Med Chem
|
| Abstract |
Two new phloroglucinol derivatives possessing chromane skeleton, petiolins A (1) and B (2), and a new phloroglucinol derivative containing a dihydrofuran ring, petiolin C (3), were isolated from aerial parts of Hypericum pseudopetiolatum var. kiusianum. The gross structures of 1-3 were elucidated by spectroscopic data, and the relative stereochemistry of 3 was elucidated by NOESY data. Petiolins A-C (1-3) showed modest cytotoxicity, while petiolin C (3) exhibited antifungal activity.
|
| Volume |
16(10)
|
| Pages |
5619-23
|
| Published |
2008-5-15
|
| DOI |
10.1016/j.bmc.2008.03.076
|
| PII |
S0968-0896(08)00310-6
|
| PMID |
18430575
|
| MeSH |
Animals
Antifungal Agents / chemistry*
Antifungal Agents / isolation & purification
Antifungal Agents / pharmacology*
Cell Line, Tumor
Cell Proliferation / drug effects
Drug Screening Assays, Antitumor
Humans
Hypericum / chemistry*
Leukemia L1210 / drug therapy*
Leukemia L1210 / pathology
Magnetic Resonance Spectroscopy / methods
Mice
Microbial Sensitivity Tests
Models, Molecular
Molecular Structure
Phloroglucinol / analogs & derivatives*
Phloroglucinol / chemistry*
Phloroglucinol / isolation & purification
Phloroglucinol / pharmacology*
Stereoisomerism
Trichophyton / drug effects*
|
| IF |
3.073
|
| Times Cited |
14
|
|
WOS Category
|
CHEMISTRY, ORGANIC
CHEMISTRY, MEDICINAL
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| Resource |
| Pathogenic microorganisms |
NA |
