Reference - Detail
RRC ID | 47057 |
---|---|
Author | Araki A, Kubota T, Tsuda M, Mikami Y, Fromont J, Kobayashi J. |
Title | Nagelamides K and L, dimeric bromopyrrole alkaloids from sponge Agelas species. |
Journal | Org Lett |
Abstract |
Two new dimeric bromopyrrole alkaloids, nagelamides K (1) and L (2), have been isolated from Okinawan marine sponges Agelas species, and the structures and stereochemistry were elucidated from spectroscopic data. Nagelamide K (1) is a bromopyrrole alkaloid possessing a rare piperidinoiminoimidazolone ring with an aminoimidazole ring and a taurine unit, while nagelamide L (2) is a unique dimeric bromopyrrole alkaloid containing an ester linkage. Nagelamides K (1) and L (2) exhibited antimicrobial activity. |
Volume | 10(11) |
Pages | 2099-102 |
Published | 2008-6-5 |
DOI | 10.1021/ol8003904 |
PMID | 18454539 |
MeSH | Agelas / chemistry* Alkaloids / chemical synthesis Alkaloids / chemistry* Alkaloids / pharmacology* Animals Anti-Infective Agents / chemical synthesis Anti-Infective Agents / chemistry* Anti-Infective Agents / pharmacology* Dimerization Magnetic Resonance Spectroscopy Microbial Sensitivity Tests Micrococcus luteus / drug effects Pyrroles / chemical synthesis Pyrroles / chemistry* Pyrroles / pharmacology* Stereoisomerism |
IF | 6.091 |
Times Cited | 33 |
WOS Category | CHEMISTRY, ORGANIC |
Resource | |
Pathogenic microorganisms | NA |