| RRC ID |
47072
|
| Author |
Shen YC, Cheng YB, Kobayashi J, Kubota T, Takahashi Y, Mikami Y, Ito J, Lin YS.
|
| Title |
Nitrogen-containing verticillene diterpenoids from the Taiwanese soft coral Cespitularia taeniata.
|
| Journal |
J Nat Prod
|
| Abstract |
Extensive column chromatography of the ethanolic extract of the soft coral Cespitularia taeniata collected in Taiwan has resulted in the isolation of eight new nitrogen-containing verticillene diterpenes, designated cespitulactams D-K ( 1- 8), together with three known diterpenes, cespitulactams A ( 9) and B ( 10) and cespitularin F. In addition, one new derivative, 6- O-acetylcespitulactam F ( 11), was prepared from compound 3. The structures of these compounds were elucidated on the basis of spectroscopic analyses, especially HRMS and 2D NMR experiments. The cytotoxicity against human oral epidermoid carcinoma (KB) and murine L1210 leukemia cell lines and antimicrobial activities of 1- 8 and 11 were tested and evaluated. A biogenetic pathway for these novel diterpene alkaloids was also proposed.
|
| Volume |
70(12)
|
| Pages |
1961-5
|
| Published |
2007-12-1
|
| DOI |
10.1021/np078011u
|
| PMID |
18052327
|
| MeSH |
Animals
Anthozoa / chemistry*
Antineoplastic Agents / chemistry
Antineoplastic Agents / isolation & purification*
Antineoplastic Agents / pharmacology
Diterpenes / chemistry
Diterpenes / isolation & purification*
Diterpenes / pharmacology
Drug Screening Assays, Antitumor
Humans
Indole Alkaloids / chemistry
Indole Alkaloids / isolation & purification*
Indole Alkaloids / pharmacology
Mice
Models, Molecular
Molecular Conformation
Molecular Structure
Nitrogen / chemistry*
Taiwan
|
| IF |
3.782
|
| Times Cited |
19
|
|
WOS Category
|
PLANT SCIENCES
PHARMACOLOGY & PHARMACY
CHEMISTRY, MEDICINAL
|
| Resource |
| Pathogenic microorganisms |
|
