論文 - 詳細
| RRC ID | 47080 |
|---|---|
| 著者 | Ma X, Li W, Yu H, Yang Y, Li M, Xue L, Xu T. |
| タイトル | Bendless modulates JNK-mediated cell death and migration in Drosophila. |
| ジャーナル | Cell Death Differ |
| Abstract |
The TNF-JNK pathway is a highly conserved signaling pathway that regulates a wide spectrum of biological processes including cell death and migration. To further delineate this pathway, we carried out a genetic screen for dominant modifiers of the cell death phenotype triggered by ectopic expression of Eiger (Egr), the Drosophila TNF ortholog. Here we show that Bendless (Ben), an E2 ubiquitin-conjugating enzyme, modulates Egr-induced JNK activation and cell death through dTRAF2. Furthermore, Ben physically interacts with dTRAF2 and regulates Egr-induced dTRAF2 polyubiquitination. Finally, Ben is required for JNK-dependent tumor progression, cell migration, oxidative stress resistance and longevity. Our results indicate that Ben constitutes an essential component of the evolutionarily conserved TNF-JNK pathway that modulates cell death and invasion, tumor progression, stress response and lifespan in metazoans. |
| 巻・号 | 21(3) |
| ページ | 407-15 |
| 公開日 | 2014-3-1 |
| DOI | 10.1038/cdd.2013.154 |
| PII | cdd2013154 |
| PMID | 24162658 |
| PMC | PMC3921588 |
| MeSH | Animals Cell Death / physiology Cell Movement / physiology* Drosophila Drosophila Proteins / metabolism Female JNK Mitogen-Activated Protein Kinases / metabolism* MAP Kinase Signaling System Male Matrix Metalloproteinase 1 / biosynthesis Oxidative Stress / physiology TNF Receptor-Associated Factor 2 / metabolism Ubiquitin-Conjugating Enzymes / metabolism Ubiquitination |
| IF | 10.717 |
| 引用数 | 40 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
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