論文 - 詳細
| RRC ID | 47276 |
|---|---|
| 著者 | Hirano Y, Ihara K, Masuda T, Yamamoto T, Iwata I, Takahashi A, Awata H, Nakamura N, Takakura M, Suzuki Y, Horiuchi J, Okuno H, Saitoe M. |
| タイトル | Shifting transcriptional machinery is required for long-term memory maintenance and modification in Drosophila mushroom bodies. |
| ジャーナル | Nat Commun |
| Abstract |
Accumulating evidence suggests that transcriptional regulation is required for maintenance of long-term memories (LTMs). Here we characterize global transcriptional and epigenetic changes that occur during LTM storage in the Drosophila mushroom bodies (MBs), structures important for memory. Although LTM formation requires the CREB transcription factor and its coactivator, CBP, subsequent early maintenance requires CREB and a different coactivator, CRTC. Late maintenance becomes CREB independent and instead requires the transcription factor Bx. Bx expression initially depends on CREB/CRTC activity, but later becomes CREB/CRTC independent. The timing of the CREB/CRTC early maintenance phase correlates with the time window for LTM extinction and we identify different subsets of CREB/CRTC target genes that are required for memory maintenance and extinction. Furthermore, we find that prolonging CREB/CRTC-dependent transcription extends the time window for LTM extinction. Our results demonstrate the dynamic nature of stored memory and its regulation by shifting transcription systems in the MBs. |
| 巻・号 | 7 |
| ページ | 13471 |
| 公開日 | 2016-11-14 |
| DOI | 10.1038/ncomms13471 |
| PII | ncomms13471 |
| PMID | 27841260 |
| PMC | PMC5114576 |
| MeSH | Animals Animals, Genetically Modified Cyclic AMP Response Element-Binding Protein / genetics Cyclic AMP Response Element-Binding Protein / metabolism Drosophila Proteins / genetics Drosophila Proteins / metabolism Drosophila melanogaster / genetics* Drosophila melanogaster / metabolism Gene Expression Profiling / methods Gene Expression Regulation* Gene Ontology Memory, Long-Term* Mushroom Bodies / metabolism* Neurons / metabolism Transcription Factors / genetics Transcription Factors / metabolism |
| IF | 12.121 |
| 引用数 | 24 |
| WOS 分野 | NEUROSCIENCES |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 10 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | |