RRC ID 47276
著者 Hirano Y, Ihara K, Masuda T, Yamamoto T, Iwata I, Takahashi A, Awata H, Nakamura N, Takakura M, Suzuki Y, Horiuchi J, Okuno H, Saitoe M.
タイトル Shifting transcriptional machinery is required for long-term memory maintenance and modification in Drosophila mushroom bodies.
ジャーナル Nat Commun
Abstract Accumulating evidence suggests that transcriptional regulation is required for maintenance of long-term memories (LTMs). Here we characterize global transcriptional and epigenetic changes that occur during LTM storage in the Drosophila mushroom bodies (MBs), structures important for memory. Although LTM formation requires the CREB transcription factor and its coactivator, CBP, subsequent early maintenance requires CREB and a different coactivator, CRTC. Late maintenance becomes CREB independent and instead requires the transcription factor Bx. Bx expression initially depends on CREB/CRTC activity, but later becomes CREB/CRTC independent. The timing of the CREB/CRTC early maintenance phase correlates with the time window for LTM extinction and we identify different subsets of CREB/CRTC target genes that are required for memory maintenance and extinction. Furthermore, we find that prolonging CREB/CRTC-dependent transcription extends the time window for LTM extinction. Our results demonstrate the dynamic nature of stored memory and its regulation by shifting transcription systems in the MBs.
巻・号 7
ページ 13471
公開日 2016-11-14
DOI 10.1038/ncomms13471
PII ncomms13471
PMID 27841260
PMC PMC5114576
MeSH Animals Animals, Genetically Modified Cyclic AMP Response Element-Binding Protein / genetics Cyclic AMP Response Element-Binding Protein / metabolism Drosophila Proteins / genetics Drosophila Proteins / metabolism Drosophila melanogaster / genetics* Drosophila melanogaster / metabolism Gene Expression Profiling / methods Gene Expression Regulation* Gene Ontology Memory, Long-Term* Mushroom Bodies / metabolism* Neurons / metabolism Transcription Factors / genetics Transcription Factors / metabolism
IF 12.121
引用数 24
WOS 分野 NEUROSCIENCES
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