RRC ID 47307
Author Miyamoto Y, Torii T, Tanoue A, Yamauchi J.
Title VCAM1 acts in parallel with CD69 and is required for the initiation of oligodendrocyte myelination.
Journal Nat Commun
Abstract Oligodendrocytes differentiate to wrap their plasma membranes around axons, forming the myelin sheath. A neuronal cue is one of the regulator elements controlling this process. Here, we demonstrate that VCAM1, which plays a key role throughout the immune system, is also expressed in oligodendrocytes, where it regulates the initiation of myelination. VCAM1 knockout mice exhibit reduced myelin thickness. Decreased myelin thickness is also observed in mutant mice of α4 integrin, which is a neuronal VCAM1 ligand. Furthermore, CD69 is identified as one of the transcripts downregulated when VCAM1 is knocked down in oligodendrocytes. Knockdown of CD69 in mice indicates its role in myelination. Therefore, VCAM1 contributes not only to the initiation of myelination but also to its regulation through controlling the abundance of CD69, demonstrating that an intercellular molecule whose primary role is in the immune system can also play an unexpected role in the CNS.
Volume 7
Pages 13478
Published 2016-11-23
DOI 10.1038/ncomms13478
PII ncomms13478
PMID 27876794
PMC PMC5476804
MeSH Animals Antigens, CD / genetics Antigens, CD / metabolism* Antigens, Differentiation, T-Lymphocyte / genetics Antigens, Differentiation, T-Lymphocyte / metabolism* Cell Differentiation Cell Proliferation Central Nervous System / metabolism Gene Expression Regulation / physiology Integrin alpha4 / genetics Integrin alpha4 / metabolism Lectins, C-Type / genetics Lectins, C-Type / metabolism* Mice, Knockout Mice, Transgenic Myelin Sheath / physiology* Oligodendroglia / physiology* Vascular Cell Adhesion Molecule-1 / genetics Vascular Cell Adhesion Molecule-1 / metabolism*
IF 12.121
Times Cited 16
Mice RBRC01461