| RRC ID |
4732
|
| 著者 |
Shuaibu MN, Pandey K, Wuyep PA, Yanagi T, Hirayama K, Ichinose A, Tanaka T, Kouno I.
|
| タイトル |
Castalagin from Anogeissus leiocarpus mediates the killing of Leishmania in vitro.
|
| ジャーナル |
Parasitol Res
|
| Abstract |
Stem barks of Anogeissus leiocarpus and Terminalia avicennoides widely used in Africa for treatment of some parasitic diseases were collected and made into methanolic extracts. The extracts were tested on four strains of promastigote forms of Leishmania in vitro. Solvent fractionation in aqueous, butanolic, and ethyl acetate layer indicated butanol and aqueous fractions to have a superior leishmanicidal activity. Chromatographic separation of the butanolic fraction on Sephadex LH-20 followed by nuclear magnetic resonance and correlation high-performance liquid chromatography revealed the presence of known hydrolyzable tannins and some related compounds-with castalagin as the major compound. The observed activity ranged from 62.5 to > or =150, 112.5 to > or =500, and 55 to >150 microg/ml for the crude methanolic extract, different solvent fractions, and the isolated compounds, respectively, on the four different Leishmania strains.
|
| 巻・号 |
103(6)
|
| ページ |
1333-8
|
| 公開日 |
2008-11-1
|
| DOI |
10.1007/s00436-008-1137-7
|
| PMID |
18690475
|
| MeSH |
Animals
Combretaceae / chemistry*
Hydrolyzable Tannins / analysis
Hydrolyzable Tannins / isolation & purification
Hydrolyzable Tannins / pharmacology*
Leishmania / classification
Leishmania / drug effects*
Medicine, African Traditional
Parasitic Sensitivity Tests
Plant Bark / chemistry*
Plant Extracts / chemistry
Plant Extracts / pharmacology
Plant Stems / chemistry*
Plants, Medicinal / chemistry
|
| IF |
1.641
|
| 引用数 |
28
|
|
WOS 分野
|
PARASITOLOGY
|
| リソース情報 |
| 病原微生物 |
Leishmania aethiopica
Leishmania amazonensis
Leishmania donovani |
