Reference - Detail
| RRC ID | 4733 |
|---|---|
| Author | Shuaibu MN, Wuyep PT, Yanagi T, Hirayama K, Ichinose A, Tanaka T, Kouno I. |
| Title | Trypanocidal activity of extracts and compounds from the stem bark of Anogeissus leiocarpus and Terminalia avicennoides. |
| Journal | Parasitol Res |
| Abstract |
The antitrypanosomal activity of methanolic extracts of Anogeissus leiocarpus and Terminalia avicennoides were evaluated in vitro against four strains of Trypanosoma species with minimum inhibitory concentration (MIC) value range of 12.5-50 mg/ml. Successive fractionations of the two plant extracts in water, butanol and ethyl acetate gave a range of activity (MIC, 20 to > or =50 microg/ml). Activity-guided and chromatographic analysis of butanolic fractions on Sephadex LH-20 column followed by high-performance liquid chromatography, nuclear magnetic resonance analysis and both ultraviolet and thin layer chromatography revealed hydrolysable tannins with a range of activity (MIC, 7.5-27.5 microg/ml or 14-91 microM). Effect of the compounds on fibroblasts did not reveal serious toxicity at moderate concentration but is concentration dependent. |
| Volume | 102(4) |
| Pages | 697-703 |
| Published | 2008-3-1 |
| DOI | 10.1007/s00436-007-0815-1 |
| PMID | 18066599 |
| MeSH | Animals Brain / cytology Brain / drug effects Cells, Cultured Combretaceae / chemistry* Fibroblasts / drug effects Medicine, African Traditional Mice Parasitic Sensitivity Tests Plant Bark / chemistry Plant Extracts / chemistry Plant Extracts / pharmacology* Plant Extracts / toxicity Plant Stems / chemistry Plants, Medicinal / chemistry Terminalia / chemistry* Trypanocidal Agents / chemistry Trypanocidal Agents / pharmacology* Trypanocidal Agents / toxicity Trypanosoma / classification Trypanosoma / drug effects* |
| IF | 1.641 |
| Times Cited | 37 |
| WOS Category | PARASITOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 2 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Pathogenic microorganisms | Trypanosoma brucei brucei Trypanosoma brucei gambiense Trypanosoma brucei rhodesiense Trypanosoma evansi |