| RRC ID |
4733
|
| Author |
Shuaibu MN, Wuyep PT, Yanagi T, Hirayama K, Ichinose A, Tanaka T, Kouno I.
|
| Title |
Trypanocidal activity of extracts and compounds from the stem bark of Anogeissus leiocarpus and Terminalia avicennoides.
|
| Journal |
Parasitol Res
|
| Abstract |
The antitrypanosomal activity of methanolic extracts of Anogeissus leiocarpus and Terminalia avicennoides were evaluated in vitro against four strains of Trypanosoma species with minimum inhibitory concentration (MIC) value range of 12.5-50 mg/ml. Successive fractionations of the two plant extracts in water, butanol and ethyl acetate gave a range of activity (MIC, 20 to > or =50 microg/ml). Activity-guided and chromatographic analysis of butanolic fractions on Sephadex LH-20 column followed by high-performance liquid chromatography, nuclear magnetic resonance analysis and both ultraviolet and thin layer chromatography revealed hydrolysable tannins with a range of activity (MIC, 7.5-27.5 microg/ml or 14-91 microM). Effect of the compounds on fibroblasts did not reveal serious toxicity at moderate concentration but is concentration dependent.
|
| Volume |
102(4)
|
| Pages |
697-703
|
| Published |
2008-3-1
|
| DOI |
10.1007/s00436-007-0815-1
|
| PMID |
18066599
|
| MeSH |
Animals
Brain / cytology
Brain / drug effects
Cells, Cultured
Combretaceae / chemistry*
Fibroblasts / drug effects
Medicine, African Traditional
Mice
Parasitic Sensitivity Tests
Plant Bark / chemistry
Plant Extracts / chemistry
Plant Extracts / pharmacology*
Plant Extracts / toxicity
Plant Stems / chemistry
Plants, Medicinal / chemistry
Terminalia / chemistry*
Trypanocidal Agents / chemistry
Trypanocidal Agents / pharmacology*
Trypanocidal Agents / toxicity
Trypanosoma / classification
Trypanosoma / drug effects*
|
| IF |
1.641
|
| Times Cited |
37
|
|
WOS Category
|
PARASITOLOGY
|
| Resource |
| Pathogenic microorganisms |
Trypanosoma brucei brucei
Trypanosoma brucei gambiense
Trypanosoma brucei rhodesiense
Trypanosoma evansi |
