RRC ID 47443
Author Suto JI.
Title Locus on chromosome 16 is significantly associated with increased tendency to lose pups in females of the RR/Sgn inbred mouse strain.
Journal Congenit Anom (Kyoto)
Abstract Females of the inbred mouse strain RR/Sgn have an apparent tendency to lose pups during rearing. To identify genes underlying this abnormal maternal phenotype, we performed quantitative trait loci (QTL) mapping in 349 (C57BL/6 J × RR/Sgn) F1  × RR/Sgn backcross mice and identified one significant and one suggestive QTL on chromosomes 16 and 4, respectively. We assigned the gene symbol nurturing ability QTL 3 (Naq3) to the QTL on chromosome 16. Twenty of the 21 mothers who lost entire litters were homozygous for RR/Sgn allele at Naq3; i.e., the significant association of Naq3 with pup loss was further confirmed by binomial tests. We tentatively propose that Mapk1, Kalrn, and Vps8 are potential candidate genes for Naq3.
Volume 57(2)
Pages 57-60
Published 2017-3-1
DOI 10.1111/cga.12199
PMID 28079294
MeSH Abortion, Spontaneous / genetics* Alleles Animals Chromosome Mapping Chromosomes, Human, Pair 16 / genetics* Embryo Loss / genetics* Female Humans Male Mice Mice, Inbred C57BL Mice, Inbred Strains Mothers Phenotype Quantitative Trait Loci*
IF 1.761
Times Cited 0
Mice RBRC01672