論文 - 詳細
| RRC ID | 47599 |
|---|---|
| 著者 | Wu CZ, Jang JH, Ahn JS, Hong YS. |
| タイトル | New geldanamycin analogs from Streptomyces hygroscopicus. |
| ジャーナル | J Microbiol Biotechnol |
| Abstract |
Geldanamycin (GM) and its analogs are important anticancer agents that inhibit heat shock protein (Hsp) 90, which is a major chaperone protein in cancer cells. Accordingly, based on interest in obtaining novel natural GM derivatives, the potential of Streptomyces hygroscopicus JCM4427, a GM producer, was explored for novel natural GM derivative(s), resulting in the discovery of new GM analogs as a biosynthetic shunt product and intermediates from its fermentation broth. In this study, the fermentation, isolation, structure determination, and biological activity of the compounds, two new tetracyclic thiazinogeldanamycin (1) and 19-hydroxy-4,5-dihydrogeldanamycin (3), together with the three known 4,5-dihydrothiazinogeldanamycin (2), reblastatin (4), and 17-demethoxy-reblastatin (5), are described. |
| 巻・号 | 22(11) |
| ページ | 1478-81 |
| 公開日 | 2012-11-1 |
| DOI | 10.4014/jmb.1206.06026 |
| PII | JMB022-11-04 |
| PMID | 23124337 |
| MeSH | Benzoquinones / chemistry Benzoquinones / metabolism* Benzoquinones / pharmacology HSP90 Heat-Shock Proteins / antagonists & inhibitors Humans Lactams, Macrocyclic / chemistry Lactams, Macrocyclic / metabolism* Lactams, Macrocyclic / pharmacology Molecular Structure Streptomyces / chemistry Streptomyces / metabolism* |
| IF | 1.992 |
| 引用数 | 16 |
| WOS 分野 | BIOTECHNOLOGY & APPLIED MICROBIOLOGY MICROBIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| 一般微生物 | JCM 4427 |