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  • 18 Hits
  • Search Condition : Filter (MeSH = Lactams, Macrocyclic / pharmacology)
Species Resource Title
Human and Animal Cells Ba/F3(RCB0805) Analysis of lorlatinib analogs reveals a roadmap for targeting diverse compound resistance mutations in ALK-positive lung cancer.
Human and Animal Cells Ba/F3 Two novel ALK mutations mediate acquired resistance to the next-generation ALK inhibitor alectinib.
Human and Animal Cells Ba/F3 Sequential ALK Inhibitors Can Select for Lorlatinib-Resistant Compound ALK Mutations in ALK-Positive Lung Cancer.
Human and Animal Cells PC-9(RCB4455) Inhibition of heat shock protein 90 destabilizes receptor tyrosine kinase ROR1 in lung adenocarcinoma.
Human and Animal Cells Ba/F3 The new-generation selective ROS1/NTRK inhibitor DS-6051b overcomes crizotinib resistant ROS1-G2032R mutation in preclinical models.
Drosophila Little effect of HSP90 inhibition on the quantitative wing traits variation in Drosophila melanogaster.
General Microbes JCM 4427 New geldanamycin analogs from Streptomyces hygroscopicus.
Human and Animal Cells HL60(RCB0041) Rubratoxin-B-induced secretion of chemokine ligands of cysteine-cysteine motif chemokine receptor 5 (CCR5) and its dependence on heat shock protein 90 in HL60 cells.
Human and Animal Cells HSP90 is crucial for regulation of LAT expression in activated T cells.
Arabidopsis / Cultured plant cells, genes rpc00008 Heat shock protein 90 acts in brassinosteroid signaling through interaction with BES1/BZR1 transcription factor.
Human and Animal Cells HFL-III(RCB0523) The combination of Hsp90 inhibitor 17AAG and heavy-ion irradiation provides effective tumor control in human lung cancer cells.
Human and Animal Cells SK-N-SH(RCB0426) Inhibition of heat shock protein 90 attenuates adenylate cyclase sensitization after chronic morphine treatment.
Human and Animal Cells IEC 6(RCB0993) Evidence for enhanced cytoprotective function of HSP90-overexpressing small intestinal epithelial cells.
General Microbes JCM 4427 Rational biosynthetic engineering for optimization of geldanamycin analogues.
Yeast NA Comprehensive screening of human genes with inhibitory effects on yeast growth and validation of a yeast cell-based system for screening chemicals.
DNA material pCMV-MAZ pCMV-MAZi (RDB03219) Mechanisms by which interleukin-6 regulates prostate-specific antigen gene expression in prostate LNCaP carcinoma cells.
Drosophila Heat shock transcription factor 1-activating compounds suppress polyglutamine-induced neurodegeneration through induction of multiple molecular chaperones.
Arabidopsis / Cultured plant cells, genes rpc00008 The 26S proteasome function and Hsp90 activity involved in the regulation of HsfA2 expression in response to oxidative stress.