Reference - Detail
| RRC ID | 47626 |
|---|---|
| Author | Tanabe Y, Masu M, Ishii T, Shigemoto R, Nakanishi S. |
| Title | A family of metabotropic glutamate receptors. |
| Journal | Neuron |
| Abstract |
Three cDNA clones, mGluR2, mGluR3, and mGluR4, were isolated from a rat brain cDNA library by cross-hybridization with the cDNA for a metabotropic glutamate receptor (mGluR1). The cloned receptors show considerable sequence similarity with mGluR1 and possess a large extracellular domain preceding the seven putative membrane-spanning segments. mGluR2 is expressed in some particular neuronal cells different from those expressing mGluR1 and mediates an efficient inhibition of forskolin-stimulated cAMP formation in cDNA-transfected cells. The mGluRs thus form a novel family of G protein-coupled receptors that differ in their signal transduction and expression patterns. |
| Volume | 8(1) |
| Pages | 169-79 |
| Published | 1992-1-1 |
| DOI | 10.1016/0896-6273(92)90118-w |
| PII | 0896-6273(92)90118-W |
| PMID | 1309649 |
| MeSH | Amino Acid Sequence Animals Base Sequence Brain Chemistry CHO Cells Cell Membrane / chemistry Cerebellum / chemistry Cerebral Cortex / chemistry Cloning, Molecular Colforsin / pharmacology Cricetinae Cyclic AMP / biosynthesis DNA / chemistry DNA / isolation & purification Gene Expression Molecular Sequence Data Nucleic Acid Hybridization Olfactory Bulb / chemistry RNA, Messenger / analysis Rats Receptors, Glutamate Receptors, Neurotransmitter / chemistry Receptors, Neurotransmitter / genetics* Signal Transduction Tissue Distribution Transfection |
| IF | 14.415 |
| Times Cited | 941 |
| WOS Category | NEUROSCIENCES |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 102 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| DNA material | pmGR1 (beta) (RDB13195) pmGR 2 (RDB13196) pmGR 3 (RDB13197) pmGR 4 (RDB13198). |