| RRC ID |
47627
|
| Author |
Masu M, Tanabe Y, Tsuchida K, Shigemoto R, Nakanishi S.
|
| Title |
Sequence and expression of a metabotropic glutamate receptor.
|
| Journal |
Nature
|
| Abstract |
The complementary DNA of a metabotropic glutamate receptor coupled to inositol phosphate/Ca2+ signal transduction has been cloned and characterized. This receptor shows no sequence similarity to conventional G protein-coupled receptors and has a unique structure with large hydrophilic sequences at both sides of seven putative membrane-spanning domains. Abundant expression of this messenger RNA is observed in neuronal cells in hippocampal dentate gyrus and CA2-3 and in cerebellar Purkinje cells, suggesting the importance of this receptor in specific hippocampal and cerebellar functions.
|
| Volume |
349(6312)
|
| Pages |
760-5
|
| Published |
1991-2-28
|
| DOI |
10.1038/349760a0
|
| PMID |
1847995
|
| MeSH |
Amino Acid Sequence
Animals
Base Sequence
Cerebellum / metabolism
Cloning, Molecular
Electrophysiology / methods
Female
Glutamates / metabolism
Glutamates / pharmacology*
Models, Structural
Molecular Sequence Data
Nucleic Acid Hybridization
Oocytes / drug effects
Oocytes / physiology
Protein Conformation
RNA, Messenger / analysis
RNA, Messenger / genetics
Rats
Receptors, Glutamate
Receptors, Neurotransmitter / drug effects
Receptors, Neurotransmitter / genetics*
Receptors, Neurotransmitter / physiology
Sequence Homology, Nucleic Acid
Xenopus
|
| IF |
42.779
|
| Times Cited |
1062
|
|
WOS Category
|
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| Resource |
| DNA material |
pmGR1 (alpha) (RDB13194) |
