論文 - 詳細
| RRC ID | 47667 |
|---|---|
| 著者 | Sahu A, Ghosh R, Deshpande G, Prasad M. |
| タイトル | A Gap Junction Protein, Inx2, Modulates Calcium Flux to Specify Border Cell Fate during Drosophila oogenesis. |
| ジャーナル | PLoS Genet |
| Abstract |
Intercellular communication mediated by gap junction (GJ) proteins is indispensable during embryogenesis, tissue regeneration and wound healing. Here we report functional analysis of a gap junction protein, Innexin 2 (Inx2), in cell type specification during Drosophila oogenesis. Our data reveal a novel involvement of Inx2 in the specification of Border Cells (BCs), a migratory cell type, whose identity is determined by the cell autonomous STAT activity. We show that Inx2 influences BC fate specification by modulating STAT activity via Domeless receptor endocytosis. Furthermore, detailed experimental analysis has uncovered that Inx2 also regulates a calcium flux that transmits across the follicle cells. We propose that Inx2 mediated calcium flux in the follicle cells stimulates endocytosis by altering Dynamin (Shibire) distribution which is in turn critical for careful calibration of STAT activation and, thus for BC specification. Together our data provide unprecedented molecular insights into how gap junction proteins can regulate cell-type specification. |
| 巻・号 | 13(1) |
| ページ | e1006542 |
| 公開日 | 2017-1-1 |
| DOI | 10.1371/journal.pgen.1006542 |
| PII | PGENETICS-D-16-01313 |
| PMID | 28114410 |
| PMC | PMC5256874 |
| MeSH | Animals Calcium / metabolism* Connexins / genetics Connexins / metabolism* Drosophila / genetics* Drosophila / growth & development Drosophila Proteins / genetics Drosophila Proteins / metabolism* Dynamins / genetics Dynamins / metabolism Endocytosis Female Oogenesis* Ovarian Follicle / cytology Ovarian Follicle / metabolism Receptors, Interleukin / genetics Receptors, Interleukin / metabolism STAT Transcription Factors / genetics STAT Transcription Factors / metabolism |
| IF | 5.175 |
| 引用数 | 9 |
| WOS 分野 | GENETICS & HEREDITY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#111858 DGRC#114609 |