RRC ID 47713
著者 Ogura Y, Sasakura Y.
タイトル Developmental Control of Cell-Cycle Compensation Provides a Switch for Patterned Mitosis at the Onset of Chordate Neurulation.
ジャーナル Dev. Cell
Abstract During neurulation of chordate ascidians, the 11th mitotic division within the epidermal layer shows a posterior-to-anterior wave that is precisely coordinated with the unidirectional progression of the morphogenetic movement. Here we show that the first sign of this patterned mitosis is an asynchronous anterior-to-posterior S-phase length and that mitotic synchrony is reestablished by a compensatory asynchronous G2-phase length. Live imaging combined with genetic experiments demonstrated that compensatory G2-phase regulation requires transcriptional activation of the G2/M regulator cdc25 by the patterning genes GATA and AP-2. The downregulation of GATA and AP-2 at the onset of neurulation leads to loss of compensatory G2-phase regulation and promotes the transition to patterned mitosis. We propose that such developmentally regulated cell-cycle compensation provides an abrupt switch to spatially patterned mitosis in order to achieve the coordination between mitotic timing and morphogenesis.
巻・号 37(2)
ページ 148-61
公開日 2016-4-20
DOI 10.1016/j.devcel.2016.03.013
PII S1534-5807(16)30158-7
PMID 27093084
MeSH Animals Cell Cycle / physiology* Chordata / metabolism Ciona intestinalis G2 Phase / physiology Mitosis / physiology* Morphogenesis / physiology* Neurulation / physiology* S Phase / physiology cdc25 Phosphatases / metabolism*
IF 9.174
引用数 4
カタユウレイボヤ・(ニッポンウミシダ) Wild C. int