論文 - 詳細
| RRC ID | 47713 |
|---|---|
| 著者 | Ogura Y, Sasakura Y. |
| タイトル | Developmental Control of Cell-Cycle Compensation Provides a Switch for Patterned Mitosis at the Onset of Chordate Neurulation. |
| ジャーナル | Dev Cell |
| Abstract |
During neurulation of chordate ascidians, the 11th mitotic division within the epidermal layer shows a posterior-to-anterior wave that is precisely coordinated with the unidirectional progression of the morphogenetic movement. Here we show that the first sign of this patterned mitosis is an asynchronous anterior-to-posterior S-phase length and that mitotic synchrony is reestablished by a compensatory asynchronous G2-phase length. Live imaging combined with genetic experiments demonstrated that compensatory G2-phase regulation requires transcriptional activation of the G2/M regulator cdc25 by the patterning genes GATA and AP-2. The downregulation of GATA and AP-2 at the onset of neurulation leads to loss of compensatory G2-phase regulation and promotes the transition to patterned mitosis. We propose that such developmentally regulated cell-cycle compensation provides an abrupt switch to spatially patterned mitosis in order to achieve the coordination between mitotic timing and morphogenesis. |
| 巻・号 | 37(2) |
| ページ | 148-61 |
| 公開日 | 2016-4-18 |
| DOI | 10.1016/j.devcel.2016.03.013 |
| PII | S1534-5807(16)30158-7 |
| PMID | 27093084 |
| MeSH | Animals Cell Cycle / physiology* Chordata / metabolism Ciona intestinalis G2 Phase / physiology Mitosis / physiology* Morphogenesis / physiology* Neurulation / physiology* S Phase / physiology cdc25 Phosphatases / metabolism* |
| IF | 10.092 |
| 引用数 | 16 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | News |
| 各媒体での言及数の合計 | 12 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| カタユウレイボヤ・(ニッポンウミシダ) | Wild C. int |