論文 - 詳細
| RRC ID | 47716 |
|---|---|
| 著者 | Kawai N, Ogura Y, Ikuta T, Saiga H, Hamada M, Sakuma T, Yamamoto T, Satoh N, Sasakura Y. |
| タイトル | Hox10-regulated endodermal cell migration is essential for development of the ascidian intestine. |
| ジャーナル | Dev Biol |
| Abstract |
Hox cluster genes play crucial roles in development of the metazoan antero-posterior axis. Functions of Hox genes in patterning the central nervous system and limb buds are well known. They are also expressed in chordate endodermal tissues, where their roles in endodermal development are still poorly understood. In the invertebrate chordate, Ciona intestinalis, endodermal tissues are in a premature state during the larval stage, and they differentiate into the digestive tract during metamorphosis. In this study, we showed that disruption of a Hox gene, Ci-Hox10, prevented intestinal formation. Ci-Hox10-knock-down larvae displayed defective migration of endodermal strand cells. Formation of a protrusion, which is important for cell migration, was disrupted in these cells. The collagen type IX gene is a downstream target of Ci-Hox10, and is negatively regulated by Ci-Hox10 and a matrix metalloproteinase ortholog, prior to endodermal cell migration. Inhibition of this regulation prevented cellular migration. These results suggest that Ci-Hox10 regulates endodermal strand cell migration by forming a protrusion and by reconstructing the extracellular matrix. |
| 巻・号 | 403(1) |
| ページ | 43-56 |
| 公開日 | 2015-7-1 |
| DOI | 10.1016/j.ydbio.2015.03.018 |
| PII | S0012-1606(15)00169-4 |
| PMID | 25888074 |
| MeSH | Animals Body Patterning / genetics Cell Differentiation Cell Movement / physiology* Ciona intestinalis / embryology* Ciona intestinalis / metabolism Collagen Type IX / biosynthesis Collagen Type IX / genetics Endoderm / cytology* Extracellular Matrix / metabolism Gene Expression Regulation, Developmental Gene Knockout Techniques Genes, Homeobox / genetics Homeodomain Proteins / genetics* Homeodomain Proteins / metabolism Intestines / cytology Intestines / embryology* |
| IF | 2.896 |
| 引用数 | 15 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| カタユウレイボヤ・(ニッポンウミシダ) | Tg[MiCiZipCifkhK]1 EJ[MiTSAdTPOG]107 Wild C. int |