Reference - Detail
| RRC ID | 47721 |
|---|---|
| Author | Oh KH, Haney JJ, Wang X, Chuang CF, Richmond JE, Kim H. |
| Title | ERG-28 controls BK channel trafficking in the ER to regulate synaptic function and alcohol response in C. elegans. |
| Journal | Elife |
| Abstract |
Voltage- and calcium-dependent BK channels regulate calcium-dependent cellular events such as neurotransmitter release by limiting calcium influx. Their plasma membrane abundance is an important factor in determining BK current and thus regulation of calcium-dependent events. In C. elegans, we show that ERG-28, an endoplasmic reticulum (ER) membrane protein, promotes the trafficking of SLO-1 BK channels from the ER to the plasma membrane by shielding them from premature degradation. In the absence of ERG-28, SLO-1 channels undergo aspartic protease DDI-1-dependent degradation, resulting in markedly reduced expression at presynaptic terminals. Loss of erg-28 suppressed phenotypic defects of slo-1 gain-of-function mutants in locomotion, neurotransmitter release, and calcium-mediated asymmetric differentiation of the AWC olfactory neuron pair, and conferred significant ethanol-resistant locomotory behavior, resembling slo-1 loss-of-function mutants, albeit to a lesser extent. Our study thus indicates that the control of BK channel trafficking is a critical regulatory mechanism for synaptic transmission and neural function. |
| Volume | 6 |
| Published | 2017-2-7 |
| DOI | 10.7554/eLife.24733 |
| PII | e24733 |
| PMID | 28168949 |
| PMC | PMC5295816 |
| MeSH | Alcohols / metabolism* Animals Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / metabolism* Carrier Proteins / metabolism* Endoplasmic Reticulum / metabolism* Large-Conductance Calcium-Activated Potassium Channels / metabolism* Membrane Proteins / metabolism* Protein Transport Synapses / physiology* |
| IF | 7.08 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 3 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| C.elegans | tm6168 |