論文 - 詳細
| RRC ID | 47786 |
|---|---|
| 著者 | Ohtsuka H, Takinami M, Shimasaki T, Hibi T, Murakami H, Aiba H. |
| タイトル | Sulfur restriction extends fission yeast chronological lifespan through Ecl1 family genes by downregulation of ribosome. |
| ジャーナル | Mol Microbiol |
| Abstract |
Nutritional restrictions such as calorie restrictions are known to increase the lifespan of various organisms. Here, we found that a restriction of sulfur extended the chronological lifespan (CLS) of the fission yeast Schizosaccharomyces pombe. The restriction decreased cellular size, RNA content, and ribosomal proteins and increased sporulation rate. These responses depended on Ecl1 family genes, the overexpression of which results in the extension of CLS. We also showed that the Zip1 transcription factor results in the sulfur restriction-dependent expression of the ecl1+ gene. We demonstrated that a decrease in ribosomal activity results in the extension of CLS. Based on these observations, we propose that sulfur restriction extends CLS through Ecl1 family genes in a ribosomal activity-dependent manner. |
| 巻・号 | 105(1) |
| ページ | 84-97 |
| 公開日 | 2017-7-1 |
| DOI | 10.1111/mmi.13686 |
| PMID | 28388826 |
| MeSH | Down-Regulation / genetics Gene Expression Regulation, Fungal / genetics Nuclear Proteins / genetics* Nuclear Proteins / metabolism* Ribosomes / metabolism Schizosaccharomyces / genetics Schizosaccharomyces / metabolism Schizosaccharomyces pombe Proteins / genetics* Schizosaccharomyces pombe Proteins / metabolism* Sulfur / metabolism Transcription Factors / metabolism |
| IF | 3.418 |
| 引用数 | 4 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY MICROBIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 酵母 | FY24017(JY1) FY24018(JY333) |