RRC ID 47786
著者 Ohtsuka H, Takinami M, Shimasaki T, Hibi T, Murakami H, Aiba H.
タイトル Sulfur restriction extends fission yeast chronological lifespan through Ecl1 family genes by downregulation of ribosome.
ジャーナル Mol Microbiol
Abstract Nutritional restrictions such as calorie restrictions are known to increase the lifespan of various organisms. Here, we found that a restriction of sulfur extended the chronological lifespan (CLS) of the fission yeast Schizosaccharomyces pombe. The restriction decreased cellular size, RNA content, and ribosomal proteins and increased sporulation rate. These responses depended on Ecl1 family genes, the overexpression of which results in the extension of CLS. We also showed that the Zip1 transcription factor results in the sulfur restriction-dependent expression of the ecl1+ gene. We demonstrated that a decrease in ribosomal activity results in the extension of CLS. Based on these observations, we propose that sulfur restriction extends CLS through Ecl1 family genes in a ribosomal activity-dependent manner.
巻・号 105(1)
ページ 84-97
公開日 2017-7-1
DOI 10.1111/mmi.13686
PMID 28388826
MeSH Down-Regulation / genetics Gene Expression Regulation, Fungal / genetics Nuclear Proteins / genetics* Nuclear Proteins / metabolism* Ribosomes / metabolism Schizosaccharomyces / genetics Schizosaccharomyces / metabolism Schizosaccharomyces pombe Proteins / genetics* Schizosaccharomyces pombe Proteins / metabolism* Sulfur / metabolism Transcription Factors / metabolism
IF 3.418
引用数 4
WOS 分野 BIOCHEMISTRY & MOLECULAR BIOLOGY MICROBIOLOGY
リソース情報
酵母 FY24017(JY1) FY24018(JY333)