論文 - 詳細
| RRC ID | 47917 |
|---|---|
| 著者 | Nitta Y, Sugie A. |
| タイトル | DISCO interacting protein 2 determines direction of axon projection under the regulation of c-Jun N-terminal kinase in the Drosophila mushroom body. |
| ジャーナル | Biochem Biophys Res Commun |
| Abstract |
Precisely controlled axon guidance for complex neuronal wiring is essential for appropriate neuronal function. c-Jun N-terminal kinase (JNK) was found to play a role in axon guidance recently as well as in cell proliferation, protection and apoptosis. In spite of many genetic and molecular studies on these biological processes regulated by JNK, how JNK regulates axon guidance accurately has not been fully explained thus far. To address this question, we use the Drosophila mushroom body (MB) as a model since the α/β axons project in two distinct directions. Here we show that DISCO interacting protein 2 (DIP2) is required for the accurate direction of axonal guidance. DIP2 expression is under the regulation of Basket (Bsk), the Drosophila homologue of JNK. We additionally found that the Bsk/DIP2 pathway is independent from the AP-1 transcriptional factor complex pathway, which is directly activated by Bsk. In conclusion, our findings revealed DIP2 as a novel effector downstream of Bsk modulating the direction of axon projection. |
| 巻・号 | 487(1) |
| ページ | 116-121 |
| 公開日 | 2017-5-20 |
| DOI | 10.1016/j.bbrc.2017.04.028 |
| PII | S0006-291X(17)30684-8 |
| PMID | 28396149 |
| MeSH | Animals Axon Guidance / physiology* Axons / physiology* Axons / ultrastructure Cells, Cultured Drosophila / physiology Drosophila Proteins / metabolism* Gene Expression Regulation, Developmental / physiology* JNK Mitogen-Activated Protein Kinases / metabolism* Morphogenesis / physiology* Mushroom Bodies / physiology Nerve Tissue Proteins / metabolism* |
| IF | 2.985 |
| 引用数 | 2 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY BIOPHYSICS |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | 7020R-2 |