RRC ID 47917
Author Nitta Y, Sugie A.
Title DISCO interacting protein 2 determines direction of axon projection under the regulation of c-Jun N-terminal kinase in the Drosophila mushroom body.
Journal Biochem Biophys Res Commun
Abstract Precisely controlled axon guidance for complex neuronal wiring is essential for appropriate neuronal function. c-Jun N-terminal kinase (JNK) was found to play a role in axon guidance recently as well as in cell proliferation, protection and apoptosis. In spite of many genetic and molecular studies on these biological processes regulated by JNK, how JNK regulates axon guidance accurately has not been fully explained thus far. To address this question, we use the Drosophila mushroom body (MB) as a model since the α/β axons project in two distinct directions. Here we show that DISCO interacting protein 2 (DIP2) is required for the accurate direction of axonal guidance. DIP2 expression is under the regulation of Basket (Bsk), the Drosophila homologue of JNK. We additionally found that the Bsk/DIP2 pathway is independent from the AP-1 transcriptional factor complex pathway, which is directly activated by Bsk. In conclusion, our findings revealed DIP2 as a novel effector downstream of Bsk modulating the direction of axon projection.
Volume 487(1)
Pages 116-121
Published 2017-5-20
DOI 10.1016/j.bbrc.2017.04.028
PII S0006-291X(17)30684-8
PMID 28396149
MeSH Animals Axon Guidance / physiology* Axons / physiology* Axons / ultrastructure Cells, Cultured Drosophila / physiology Drosophila Proteins / metabolism* Gene Expression Regulation, Developmental / physiology* JNK Mitogen-Activated Protein Kinases / metabolism* Morphogenesis / physiology* Mushroom Bodies / physiology Nerve Tissue Proteins / metabolism*
IF 2.985
Times Cited 2
Drosophila 7020R-2