Reference - Detail
| RRC ID | 47965 |
|---|---|
| Author | Yu T, Graf M, Renn J, Schartl M, Larionova D, Huysseune A, Witten PE, Winkler C. |
| Title | A vertebrate-specific and essential role for osterix in osteogenesis revealed by gene knockout in the teleost medaka. |
| Journal | Development |
| Abstract |
osterix (osx; sp7) encodes a zinc-finger transcription factor that controls osteoblast differentiation in mammals. Although identified in all vertebrate lineages, its role in non-mammalian bone formation remains elusive. Here, we show that an osx mutation in medaka results in severe bone defects and larval lethality. Pre-osteoblasts fail to differentiate leading to severe intramembranous and perichondral ossification defects. The notochord sheath mineralizes normally, supporting the idea of an osteoblast-independent mechanism for teleost vertebral centra formation. This study establishes a key role for Osx for bone formation in a non-mammalian species, and reveals conserved and non-conserved features in vertebrate bone formation. |
| Volume | 144(2) |
| Pages | 265-271 |
| Published | 2017-1-15 |
| DOI | 10.1242/dev.139550 |
| PII | dev.139550 |
| PMID | 27993982 |
| MeSH | Animals Animals, Genetically Modified Calcification, Physiologic / genetics Gene Expression Regulation, Developmental Gene Knockout Techniques Notochord / embryology Oryzias / embryology* Oryzias / genetics* Osteogenesis / genetics* Phylogeny Sp7 Transcription Factor Species Specificity Transcription Factors / genetics Transcription Factors / physiology* Vertebrates / embryology Vertebrates / genetics Zebrafish Proteins / physiology |
| IF | 5.611 |
| Times Cited | 17 |
| WOS Category | DEVELOPMENTAL BIOLOGY |
| Altmetric score |
オルトメトリクス指標項目
|
| Total number of mentions | 0 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Medaka | osx_tv1mutant/osx:mCherry (TG1138) col10a1:nlGFP (TG1129) |