RRC ID 4799
Author Date-Ito A, Ohara H, Ichikawa M, Mori Y, Hagino-Yamagishi K.
Title Xenopus V1R vomeronasal receptor family is expressed in the main olfactory system.
Journal Chem. Senses
Abstract To date, over 100 vomeronasal receptor type 1 (V1R) genes have been identified in rodents. V1R is specifically expressed in the rodent vomeronasal organ (VNO) and is thought to be responsible for pheromone reception. Recently, 21 putatively functional V1R genes were identified in the genome database of the amphibian Xenopus tropicalis. Amphibians are the first vertebrates to possess a VNO. In order to determine at which point during evolution the vertebrate V1R genes began to function in the vomeronasal system, we analyzed the expression of all putatively functional V1R genes in Xenopus olfactory organs. We found that V1R expression was not detected in the VNO but was specifically detected in the main olfactory epithelium (MOE). We also observed that V1R-expressing cells in the MOE coexpressed Gi2, thus suggesting that the V1R-Gi2-mediated signal transduction pathway, which is considered to play an important role in pheromone reception in the rodent VNO, exists in the amphibian MOE. These results suggest that V1R-mediated signal transduction pathway functions in Xenopus main olfactory system.
Volume 33(4)
Pages 339-46
Published 2008-4
DOI 10.1093/chemse/bjm090
PII bjm090
PMID 18238827
MeSH Animals Cloning, Molecular GTP-Binding Protein alpha Subunit, Gi2 / biosynthesis GTP-Binding Protein alpha Subunit, Gi2 / genetics Gene Expression In Situ Hybridization Olfactory Mucosa / metabolism* Pseudogenes / genetics Receptors, Pheromone / biosynthesis* Receptors, Pheromone / genetics Signal Transduction Vomeronasal Organ / metabolism* Xenopus Xenopus Proteins / biosynthesis* Xenopus Proteins / genetics
IF 2.336
Times Cited 34
WOS Category FOOD SCIENCE & TECHNOLOGY PHYSIOLOGY BEHAVIORAL SCIENCES NEUROSCIENCES
Resource
Xenopus tropicalis