Reference - Detail
| RRC ID | 48014 |
|---|---|
| Author | Chiken S, Nambu A. |
| Title | Mechanism of Deep Brain Stimulation: Inhibition, Excitation, or Disruption? |
| Journal | Neuroscientist |
| Abstract |
Deep brain stimulation (DBS), applying high-frequency electrical stimulation to deep brain structures, has now provided an effective therapeutic option for treatment of various neurological and psychiatric disorders. DBS targeting the internal segment of the globus pallidus, subthalamic nucleus, and thalamus is used to treat symptoms of movement disorders, such as Parkinson's disease, dystonia, and tremor. However, the mechanism underlying the beneficial effects of DBS remains poorly understood and is still under debate: Does DBS inhibit or excite local neuronal elements? In this short review, we would like to introduce our recent work on the physiological mechanism of DBS and propose an alternative explanation: DBS dissociates input and output signals, resulting in the disruption of abnormal information flow through the stimulation site. |
| Volume | 22(3) |
| Pages | 313-22 |
| Published | 2016-6-1 |
| DOI | 10.1177/1073858415581986 |
| PII | 1073858415581986 |
| PMID | 25888630 |
| PMC | PMC4871171 |
| MeSH | Action Potentials Animals Basal Ganglia / physiopathology Brain / physiopathology* Cerebral Cortex / physiopathology Deep Brain Stimulation* Humans Models, Neurological* Neural Inhibition* Neural Pathways / physiopathology Neurons / physiology* Parkinson Disease / physiopathology* Parkinson Disease / therapy* Subthalamic Nucleus / physiopathology |
| IF | 6.5 |
| Times Cited | 99 |
| WOS Category | CLINICAL NEUROLOGY NEUROSCIENCES |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 12 |
| Altmetric score changes over past 6months | 0.0 |
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| Japanese macaques | |