論文 - 詳細
| RRC ID | 48027 |
|---|---|
| 著者 | Nagai Y, Kikuchi E, Lerchner W, Inoue KI, Ji B, Eldridge MA, Kaneko H, Kimura Y, Oh-Nishi A, Hori Y, Kato Y, Hirabayashi T, Fujimoto A, Kumata K, Zhang MR, Aoki I, Suhara T, Higuchi M, Takada M, Richmond BJ, Minamimoto T. |
| タイトル | PET imaging-guided chemogenetic silencing reveals a critical role of primate rostromedial caudate in reward evaluation. |
| ジャーナル | Nat Commun |
| Abstract |
The rostromedial caudate (rmCD) of primates is thought to contribute to reward value processing, but a causal relationship has not been established. Here we use an inhibitory DREADD (Designer Receptor Exclusively Activated by Designer Drug) to repeatedly and non-invasively inactivate rmCD of macaque monkeys. We inject an adeno-associated viral vector expressing the inhibitory DREADD, hM4Di, into the rmCD bilaterally. To visualize DREADD expression in vivo, we develop a non-invasive imaging method using positron emission tomography (PET). PET imaging provides information critical for successful chemogenetic silencing during experiments, in this case the location and level of hM4Di expression, and the relationship between agonist dose and hM4Di receptor occupancy. Here we demonstrate that inactivating bilateral rmCD through activation of hM4Di produces a significant and reproducible loss of sensitivity to reward value in monkeys. Thus, the rmCD is involved in making normal judgments about the value of reward. |
| 巻・号 | 7 |
| ページ | 13605 |
| 公開日 | 2016-12-6 |
| DOI | 10.1038/ncomms13605 |
| PII | ncomms13605 |
| PMID | 27922009 |
| PMC | PMC5150653 |
| MeSH | Animals Behavior, Animal / drug effects Caudate Nucleus / diagnostic imaging* Caudate Nucleus / drug effects Gene Silencing* Macaca Muscimol / pharmacology Positron-Emission Tomography* Reward* |
| IF | 12.121 |
| 引用数 | 25 |
| WOS 分野 | NEUROSCIENCES |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 21 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ニホンザル | |