RRC ID 48102
Author Takumi T, Ohkubo H, Nakanishi S.
Title Cloning of a membrane protein that induces a slow voltage-gated potassium current.
Journal Science
Abstract A rat kidney messenger RNA that induces a slowly activating, voltage-dependent potassium current on its expression in Xenopus oocytes was identified by combining molecular cloning with an electrophysiological assay. The cloned complementary DNA encodes a novel membrane protein that consists of 130 amino acids with a single putative transmembrane domain. This protein differs from the known ion channel proteins but is involved in the induction of selective permeation of potassium ions by membrane depolarization.
Volume 242(4881)
Pages 1042-5
Published 1988-11-18
DOI 10.1126/science.3194754
PMID 3194754
MeSH Amino Acid Sequence Animals Base Sequence Blotting, Northern Cloning, Molecular DNA / genetics Electric Conductivity Membrane Potentials Membrane Proteins / genetics* Molecular Sequence Data Molecular Weight Potassium Channels / physiology* Rats Xenopus laevis
IF 41.063
Times Cited 458
DNA material pKI 27 (RDB13187)