論文 - 詳細
| RRC ID | 48215 |
|---|---|
| 著者 | Tamura T, Ozawa M, Tanaka N, Arai S, Mura K. |
| タイトル | Bacillus cereus Response to a Proanthocyanidin Trimer, a Transcriptional and Functional Analysis. |
| ジャーナル | Curr Microbiol |
| Abstract |
Proanthocyanidins are abundant in peanut skin, and in this study, the antibacterial effects of a peanut skin extract (PSE) against food-borne bacteria were investigated to find its minimum inhibitory concentration. Food-borne gram-positive bacteria, and in particular Bacillus cereus, was more sensitive to PSE. In particular, the inhibitory activity of epicatechin-(4β → 6)-epicatechin-(2β → O→7, 4β → 8)-catechin (EEC), a proanthocyanidin trimer from peanut skin, against B. cereus was stronger than that of procyanidin A1, a proanthocyanidin dimer. DNA microarray analysis of B. cereus treated with EEC was carried out, with a finding that 597 genes were significantly up-regulated. Analysis of the up-regulated genes suggested that EEC disrupted the normal condition of the cell membrane and wall of B. cereus and alter its usual nutritional metabolism. Moreover, treatment of B. cereus with EEC inhibited glucose uptake, suggesting that EEC affects the cell-surface adsorption. |
| 巻・号 | 73(1) |
| ページ | 115-23 |
| 公開日 | 2016-7-1 |
| DOI | 10.1007/s00284-016-1032-x |
| PII | 10.1007/s00284-016-1032-x |
| PMID | 27061585 |
| PMC | PMC4899491 |
| MeSH | Anti-Bacterial Agents / chemistry Anti-Bacterial Agents / pharmacology* Arachis / chemistry* Bacillus cereus / drug effects* Bacillus cereus / genetics Bacillus cereus / metabolism Bacterial Proteins / genetics Bacterial Proteins / metabolism Gene Expression Regulation, Bacterial / drug effects Molecular Structure Plant Extracts / chemistry Plant Extracts / pharmacology* Proanthocyanidins / chemistry Proanthocyanidins / pharmacology* Transcription, Genetic / drug effects |
| IF | 1.746 |
| 引用数 | 6 |
| WOS 分野 | MICROBIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 一般微生物 | JCM 3752 JCM 3725 JCM 7577 |