RRC ID 48263
著者 Sriswasdi S, Takashima M, Manabe R, Ohkuma M, Sugita T, Iwasaki W.
タイトル Global deceleration of gene evolution following recent genome hybridizations in fungi.
ジャーナル Genome Res
Abstract Polyploidization events such as whole-genome duplication and inter-species hybridization are major evolutionary forces that shape genomes. Although long-term effects of polyploidization have been well-characterized, early molecular evolutionary consequences of polyploidization remain largely unexplored. Here, we report the discovery of two recent and independent genome hybridizations within a single clade of a fungal genus, Trichosporon Comparative genomic analyses revealed that redundant genes are experiencing decelerations, not accelerations, of evolutionary rates. We identified a relationship between gene conversion and decelerated evolution suggesting that gene conversion may improve the genome stability of young hybrids by restricting gene functional divergences. Furthermore, we detected large-scale gene losses from transcriptional and translational machineries that indicate a global compensatory mechanism against increased gene dosages. Overall, our findings illustrate counteracting mechanisms during an early phase of post-genome hybridization and fill a critical gap in existing theories on genome evolution.
巻・号 26(8)
ページ 1081-90
公開日 2016-8-1
DOI 10.1101/gr.205948.116
PII gr.205948.116
PMID 27440871
PMC PMC4971771
MeSH Deceleration* Evolution, Molecular* Gene Conversion Genome, Fungal / genetics* Hybridization, Genetic Phylogeny Polyploidy Trichosporon / genetics*
IF 11.093
引用数 7
WOS 分野 BIOTECHNOLOGY & APPLIED MICROBIOLOGY GENETICS & HEREDITY BIOCHEMISTRY & MOLECULAR BIOLOGY
リソース情報
一般微生物 JCM 2938 JCM 9940 JCM 2941 JCM 9195