RRC ID |
48263
|
著者 |
Sriswasdi S, Takashima M, Manabe R, Ohkuma M, Sugita T, Iwasaki W.
|
タイトル |
Global deceleration of gene evolution following recent genome hybridizations in fungi.
|
ジャーナル |
Genome Res
|
Abstract |
Polyploidization events such as whole-genome duplication and inter-species hybridization are major evolutionary forces that shape genomes. Although long-term effects of polyploidization have been well-characterized, early molecular evolutionary consequences of polyploidization remain largely unexplored. Here, we report the discovery of two recent and independent genome hybridizations within a single clade of a fungal genus, Trichosporon Comparative genomic analyses revealed that redundant genes are experiencing decelerations, not accelerations, of evolutionary rates. We identified a relationship between gene conversion and decelerated evolution suggesting that gene conversion may improve the genome stability of young hybrids by restricting gene functional divergences. Furthermore, we detected large-scale gene losses from transcriptional and translational machineries that indicate a global compensatory mechanism against increased gene dosages. Overall, our findings illustrate counteracting mechanisms during an early phase of post-genome hybridization and fill a critical gap in existing theories on genome evolution.
|
巻・号 |
26(8)
|
ページ |
1081-90
|
公開日 |
2016-8-1
|
DOI |
10.1101/gr.205948.116
|
PII |
gr.205948.116
|
PMID |
27440871
|
PMC |
PMC4971771
|
MeSH |
Deceleration*
Evolution, Molecular*
Gene Conversion
Genome, Fungal / genetics*
Hybridization, Genetic
Phylogeny
Polyploidy
Trichosporon / genetics*
|
IF |
11.093
|
引用数 |
7
|
WOS 分野
|
BIOTECHNOLOGY & APPLIED MICROBIOLOGY
GENETICS & HEREDITY
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
リソース情報 |
一般微生物 |
JCM 2938
JCM 9940
JCM 2941
JCM 9195 |