RRC ID 48265
著者 Isa K, Oka K, Beauchamp N, Sato M, Wada K, Ohtani K, Nakanishi S, McCartney E, Tanaka M, Shimizu T, Kamiya S, Kruger C, Takahashi M.
タイトル Safety assessment of the Clostridium butyricum MIYAIRI 588® probiotic strain including evaluation of antimicrobial sensitivity and presence of Clostridium toxin genes in vitro and teratogenicity in vivo.
ジャーナル Hum Exp Toxicol
Abstract Probiotics are live microorganisms ingested for the purpose of conferring a health benefit on the host. Development of new probiotics includes the need for safety evaluations that should consider factors such as pathogenicity, infectivity, virulence factors, toxicity, and metabolic activity. Clostridium butyricum MIYAIRI 588(®) (CBM 588(®)), an anaerobic spore-forming bacterium, has been developed as a probiotic for use by humans and food animals. Safety studies of this probiotic strain have been conducted and include assessment of antimicrobial sensitivity, documentation of the lack of Clostridium toxin genes, and evaluation of CBM 588(®) on reproductive and developmental toxicity in a rodent model. With the exception of aminoglycosides, to which anaerobes are intrinsically resistant, CBM 588(®) showed sensitivity to all antibiotic classes important in human and animal therapeutics. In addition, analysis of the CBM 588(®) genome established the absence of genes for encoding for α, β, or ε toxins and botulin neurotoxins types A, B, E, or F. There were no deleterious reproductive and developmental effects observed in mice associated with the administration of CBM 588(®) These data provide further support for the safety of CBM 588(®) for use as a probiotic in animals and humans.
巻・号 35(8)
ページ 818-32
公開日 2016-8-1
DOI 10.1177/0960327115607372
PII 0960327115607372
PMID 26437792
MeSH Abnormalities, Drug-Induced* / etiology Animals Anti-Bacterial Agents / pharmacology* Bacterial Toxins / genetics* Botulinum Toxins / genetics Clostridium butyricum / drug effects Clostridium butyricum / genetics* Drug Resistance, Bacterial Enterotoxins / genetics Female Male Mice Mice, Inbred ICR Microbial Sensitivity Tests Neurotoxins / genetics Pregnancy Probiotics / pharmacology Probiotics / standards Probiotics / toxicity* Reproduction / drug effects*
IF 2.067
引用数 11
WOS 分野 TOXICOLOGY
リソース情報
一般微生物 JCM 1290 JCM 3816 JCM 3817 JCM 3818 JCM 3819