RRC ID 4832
Author Miura K, Agetsuma M, Kitano H, Yoshimura A, Matsuoka M, Jacobsen SE, Ashikari M.
Title A metastable DWARF1 epigenetic mutant affecting plant stature in rice.
Journal Proc Natl Acad Sci U S A
Abstract Epigenetic mutations confer heritable changes in gene expression that are not due to changes in the underlying sequence of the DNA. We identified a spontaneous rice mutant, Epi-d1, that shows a metastable dwarf phenotype. The phenotype is mitotically and meiotically inheritable and corresponds to the metastable epigenetic silencing of the DWARF1 (D1) gene. The silenced state is correlated with repressive histone and DNA methylation marks in the D1 promoter region but is not associated with DNA sequence alterations. Compared with other known epigenetic silenced loci in plants such as paramutable maize alleles and silent Arabidopsis genes, the Epi-d1 silencing phenomenon shows a high level of bidirectional metastable mutability. Epigenetic alleles such as Epi-d1 could thus provide for rapid adaptation under selective conditions.
Volume 106(27)
Pages 11218-23
Published 2009-7-7
DOI 10.1073/pnas.0901942106
PII 0901942106
PMID 19541604
PMC PMC2708680
MeSH Chromatin Immunoprecipitation DNA Methylation / genetics Epigenesis, Genetic* Gene Expression Regulation, Plant Genes, Plant* Genotype Mutation / genetics* Oryza / anatomy & histology* Oryza / genetics* Phenotype Physical Chromosome Mapping Plant Proteins / genetics* Plant Proteins / metabolism Recombination, Genetic / genetics
IF 9.412
Times Cited 90
Arabidopsis / Cultured plant cells, genes rpd00105