論文 - 詳細
| RRC ID | 4832 |
|---|---|
| 著者 | Miura K, Agetsuma M, Kitano H, Yoshimura A, Matsuoka M, Jacobsen SE, Ashikari M. |
| タイトル | A metastable DWARF1 epigenetic mutant affecting plant stature in rice. |
| ジャーナル | Proc Natl Acad Sci U S A |
| Abstract |
Epigenetic mutations confer heritable changes in gene expression that are not due to changes in the underlying sequence of the DNA. We identified a spontaneous rice mutant, Epi-d1, that shows a metastable dwarf phenotype. The phenotype is mitotically and meiotically inheritable and corresponds to the metastable epigenetic silencing of the DWARF1 (D1) gene. The silenced state is correlated with repressive histone and DNA methylation marks in the D1 promoter region but is not associated with DNA sequence alterations. Compared with other known epigenetic silenced loci in plants such as paramutable maize alleles and silent Arabidopsis genes, the Epi-d1 silencing phenomenon shows a high level of bidirectional metastable mutability. Epigenetic alleles such as Epi-d1 could thus provide for rapid adaptation under selective conditions. |
| 巻・号 | 106(27) |
| ページ | 11218-23 |
| 公開日 | 2009-7-7 |
| DOI | 10.1073/pnas.0901942106 |
| PII | 0901942106 |
| PMID | 19541604 |
| PMC | PMC2708680 |
| MeSH | Chromatin Immunoprecipitation DNA Methylation / genetics Epigenesis, Genetic* Gene Expression Regulation, Plant Genes, Plant* Genotype Mutation / genetics* Oryza / anatomy & histology* Oryza / genetics* Phenotype Physical Chromosome Mapping Plant Proteins / genetics* Plant Proteins / metabolism Recombination, Genetic / genetics |
| IF | 9.412 |
| 引用数 | 90 |
| WOS 分野 | PLANT SCIENCES |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | F1000Research |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| シロイヌナズナ / 植物培養細胞・遺伝子 | rpd00105 |
| イネ | |