| RRC ID |
4869
|
| Author |
Mori M, Fu X, Chen L, Zhang G, Higuchi K.
|
| Title |
Hereditary pancreatitis model WBN/Kob rat strain has a unique haplotype in the Pdwk1 region on chromosome 7.
|
| Journal |
Exp Anim
|
| Abstract |
The WBN/Kob rat strain is a hereditary animal model of chronic pancreatitis and diabetes mellitus. The major WBN/Kob loci for pancreatitis (Pdwk1 and Pdwk2) are located on chromosomes 7 and X, respectively. In this study, polymorphisms were sought for candidate genes in the Pdwk1 and Pdwk2 regions. Nucleotide polymorphisms were found in 14 candidate genes examined in the Pdwk1 region. These polymorphisms were not associated with functional changes, and hence were unlikely to be a cause of pancreatitis. Seven nucleotide polymorphisms in three candidate genes, Rac2, Grap2, and Xpnpep3, located within a 3.3-Mb region were not found in 14 other inbred rat strains. These results suggest that WBN/Kob has a unique haplotype block in the chromosomal region contatining Pdwk1.
|
| Volume |
58(4)
|
| Pages |
409-13
|
| Published |
2009-7-1
|
| DOI |
10.1538/expanim.58.409
|
| PII |
JST.JSTAGE/expanim/58.409
|
| PMID |
19654439
|
| MeSH |
Amino Acid Sequence
Animals
Chromosomes, Mammalian*
Diabetes Mellitus / genetics*
Diabetes Mellitus / pathology
Disease Models, Animal
Genetic Predisposition to Disease*
Haplotypes
Male
Molecular Sequence Data
Pancreas / pathology
Pancreatitis, Chronic / genetics*
Pancreatitis, Chronic / pathology
Polymorphism, Single Nucleotide*
Rats
Rats, Inbred BN
Specific Pathogen-Free Organisms
X Chromosome*
|
| IF |
1.574
|
| Times Cited |
5
|
|
WOS Category
|
VETERINARY SCIENCES
ZOOLOGY
|
| Resource |
| Rats |
KHR/Kyo(strainID=4)
KMI/Tky(strainID=29) |
