| RRC ID |
4873
|
| Author |
Kose H, Sado Y, Yamada T, Matsumoto K.
|
| Title |
Genetic mapping found major QTLs for antibody-induced glomerulonephritis in WKY rats.
|
| Journal |
Exp Anim
|
| Abstract |
Genetic bases of glomerulonephritis, a major cause of kidney dysfunction in humans and one of the most characteristic complications of autoimmune disorders such as Goodpasture syndrome, are complex. The Wistar-Kyoto (WKY) rat strain is well characterized for its susceptibility to autoantibodies against glomerular basement membrane (GBM), however the molecular mechanisms underlining the phenotype are largely unknown. Here we performed a whole genome scan using a backcross (BC) F(1) (WKY x DA) x WKY population, for which the DA rat is a nonsusceptible control strain. We found two significant QTLs on chromosomes 1 and 12, which were involved in elevated levels of proteinuria and kidney weight index, respectively. The relevance of these QTLs with the genetic factors involved in autoimmunity and renal disease is discussed.
|
| Volume |
58(2)
|
| Pages |
193-8
|
| Published |
2009-4-1
|
| DOI |
10.1538/expanim.58.193
|
| PII |
JST.JSTAGE/expanim/58.193
|
| PMID |
19448344
|
| MeSH |
Animals
Anti-Glomerular Basement Membrane Disease / genetics*
Anti-Glomerular Basement Membrane Disease / pathology
Chromosome Mapping / methods*
Female
Genetic Markers
Genetic Predisposition to Disease
Genome
Hybridization, Genetic
Kidney / pathology
Male
Organ Size / genetics
Proteinuria / genetics
Quantitative Trait Loci / genetics*
Quantitative Trait, Heritable*
Rats
Rats, Inbred WKY / genetics*
|
| IF |
1.574
|
| Times Cited |
1
|
|
WOS Category
|
VETERINARY SCIENCES
ZOOLOGY
|
| Resource |
| Rats |
DA/Slc(strainID=380)
WKY/NCrlCrlj(strainID=477) |
