論文 - 詳細
| RRC ID | 48865 |
|---|---|
| 著者 | King AN, Barber AF, Smith AE, Dreyer AP, Sitaraman D, Nitabach MN, Cavanaugh DJ, Sehgal A. |
| タイトル | A Peptidergic Circuit Links the Circadian Clock to Locomotor Activity. |
| ジャーナル | Curr Biol |
| Abstract |
The mechanisms by which clock neurons in the Drosophila brain confer an ∼24-hr rhythm onto locomotor activity are unclear, but involve the neuropeptide diuretic hormone 44 (DH44), an ortholog of corticotropin-releasing factor. Here we identified DH44 receptor 1 as the relevant receptor for rest:activity rhythms and mapped its site of action to hugin-expressing neurons in the subesophageal zone (SEZ). We traced a circuit that extends from Dh44-expressing neurons in the pars intercerebralis (PI) through hugin+ SEZ neurons to the ventral nerve cord. Hugin neuropeptide, a neuromedin U ortholog, also regulates behavioral rhythms. The DH44 PI-Hugin SEZ circuit controls circadian locomotor activity in a daily cycle but has minimal effect on feeding rhythms, suggesting that the circadian drive to feed can be separated from circadian locomotion. These findings define a linear peptidergic circuit that links the clock to motor outputs to modulate circadian control of locomotor activity. |
| 巻・号 | 27(13) |
| ページ | 1915-1927.e5 |
| 公開日 | 2017-7-10 |
| DOI | 10.1016/j.cub.2017.05.089 |
| PII | S0960-9822(17)30697-8 |
| PMID | 28669757 |
| PMC | PMC5698909 |
| MeSH | Animals Animals, Genetically Modified / genetics Animals, Genetically Modified / physiology Circadian Clocks / genetics* Drosophila Proteins / genetics* Drosophila Proteins / metabolism Drosophila melanogaster / genetics Drosophila melanogaster / physiology* Locomotion / genetics* Male Neuropeptides / genetics* Neuropeptides / metabolism Receptors, Cell Surface / genetics* Receptors, Cell Surface / metabolism |
| IF | 9.601 |
| 引用数 | 22 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 23 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | 12370R-4 |