RRC ID 49326
著者 Tabata T, Eaton S, Kornberg TB.
タイトル The Drosophila hedgehog gene is expressed specifically in posterior compartment cells and is a target of engrailed regulation.
ジャーナル Genes Dev
Abstract cDNAs were isolated that represent transcripts of the Drosophila segment polarity gene, hedgehog (hh). Sequence analysis reveals a motif characteristic of a transmembrane domain, suggesting that the hh protein is membrane-associated. hh expression in epidermal cells is confined to the posterior compartments and coincides precisely with that of engrailed (en). Despite the similar patterns of expression in the cellular blastoderm, hh expression is independent of en, but hh expression becomes sensitive to and dependent on en during the extended germ band stage. The ectopic expression of hh that is normally induced in patched (ptc) mutant embryos does not appear in ptc en double mutants. We discuss these findings in terms of the relationship between en and hh, and the role of the hh function.
巻・号 6(12B)
ページ 2635-45
公開日 1992-12-1
DOI 10.1101/gad.6.12b.2635
PMID 1340474
MeSH Amino Acid Sequence Animals Base Sequence DNA Drosophila / genetics* Drosophila Proteins Gene Expression Regulation* Genes, Insect* Homeodomain Proteins* Insect Hormones / genetics* Molecular Sequence Data Mutation Transcription Factors / genetics*
IF 9.527
引用数 317
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