論文 - 詳細
| RRC ID | 49328 |
|---|---|
| 著者 | Tabata T, Schwartz C, Gustavson E, Ali Z, Kornberg TB. |
| タイトル | Creating a Drosophila wing de novo, the role of engrailed, and the compartment border hypothesis. |
| ジャーナル | Development |
| Abstract |
Anterior/posterior compartment borders bisect every Drosophila imaginal disc, and the engrailed gene is essential for their function. We analyzed the role of the engrailed and invected genes in wing discs by eliminating or increasing their activity. Removing engrailed/invected from posterior wing cells created two new compartments: an anterior compartment consisting of mutant cells and a posterior compartment that grew from neighboring cells. In some cases, these compartments formed a complete new wing. Increasing engrailed activity also affected patterning. These findings demonstrate that engrailed both directs the posterior compartment pathway and creates the compartment border. These findings also establish the compartment border as the pre-eminent organizational feature of disc growth and patterning. |
| 巻・号 | 121(10) |
| ページ | 3359-69 |
| 公開日 | 1995-10-1 |
| DOI | 10.1242/dev.121.10.3359 |
| PMID | 7588069 |
| MeSH | Animals Cloning, Molecular Drosophila / embryology* Drosophila / genetics Drosophila Proteins* Female Gene Deletion Gene Expression Genes, Insect* Homeodomain Proteins / genetics* Insect Hormones / genetics* Morphogenesis / genetics Phenotype Transcription Factors / genetics* Wings, Animal / embryology* |
| IF | 5.611 |
| 引用数 | 215 |
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| 最多言及媒体 | Wikipedia |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
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