RRC ID 49340
Author Kotoula V, Moressis A, Semelidou O, Skoulakis EMC.
Title Drk-mediated signaling to Rho kinase is required for anesthesia-resistant memory in Drosophila.
Journal Proc. Natl. Acad. Sci. U.S.A.
Abstract ortholog of the adaptor protein Grb2, is essential for ARM within adult mushroom body neurons. Significantly, Drk signals engage the Rho kinase Drok, implicating dynamic cytoskeletal changes in ARM, and this is supported by reduced F-actin in the mutants and after pharmacological inhibition of Drok. Interestingly, Drk-Drok signaling appears independent of the function of Radish (Rsh), a protein long implicated in ARM, suggesting that the process involves at least two distinct molecular pathways. Based on these results, we propose that signaling pathways involved in structural plasticity likely underlie this form of translation-independent memory.
Volume 114(41)
Pages 10984-10989
Published 2017-10-10
DOI 10.1073/pnas.1704835114
PII 1704835114
PMID 28973902
PMC PMC5642687
MeSH Actins / metabolism* Anesthetics / administration & dosage* Animals Animals, Genetically Modified / genetics Animals, Genetically Modified / metabolism Cytoskeleton / metabolism* Drosophila Proteins / genetics Drosophila Proteins / metabolism* Drosophila melanogaster / drug effects Drosophila melanogaster / physiology* Drug Resistance Memory / drug effects Memory / physiology* Mushroom Bodies / physiology Signal Transduction rho-Associated Kinases / genetics rho-Associated Kinases / metabolism*
IF 9.504
Resource
Drosophila 9774R-3