論文 - 詳細
| RRC ID | 49518 |
|---|---|
| 著者 | Banerjee JJ, Aerne BL, Holder MV, Hauri S, Gstaiger M, Tapon N. |
| タイトル | Meru couples planar cell polarity with apical-basal polarity during asymmetric cell division. |
| ジャーナル | Elife |
| Abstract |
Polarity is a shared feature of most cells. In epithelia, apical-basal polarity often coexists, and sometimes intersects with planar cell polarity (PCP), which orients cells in the epithelial plane. From a limited set of core building blocks (e.g. the Par complexes for apical-basal polarity and the Frizzled/Dishevelled complex for PCP), a diverse array of polarized cells and tissues are generated. This suggests the existence of little-studied tissue-specific factors that rewire the core polarity modules to the appropriate conformation. In Drosophila sensory organ precursors (SOPs), the core PCP components initiate the planar polarization of apical-basal determinants, ensuring asymmetric division into daughter cells of different fates. We show that Meru, a RASSF9/RASSF10 homologue, is expressed specifically in SOPs, recruited to the posterior cortex by Frizzled/Dishevelled, and in turn polarizes the apical-basal polarity factor Bazooka (Par3). Thus, Meru belongs to a class of proteins that act cell/tissue-specifically to remodel the core polarity machinery. |
| 巻・号 | 6 |
| 公開日 | 2017-6-30 |
| DOI | 10.7554/eLife.25014 |
| PII | e25014 |
| PMID | 28665270 |
| PMC | PMC5493435 |
| MeSH | Animals Asymmetric Cell Division* Cell Polarity* Drosophila / embryology* Drosophila Proteins / physiology* Gene Expression Profiling Gene Expression Regulation, Developmental* Vesicular Transport Proteins / physiology* |
| IF | 7.08 |
| 引用数 | 6 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 11 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 3.0 |
| リソース情報 | |
| ショウジョウバエ | 5055R-2 17697R-2 |