論文 - 詳細
| RRC ID | 49587 |
|---|---|
| 著者 | Ríos-Barrera LD, Sigurbjörnsdóttir S, Baer M, Leptin M. |
| タイトル | Dual function for Tango1 in secretion of bulky cargo and in ER-Golgi morphology. |
| ジャーナル | Proc Natl Acad Sci U S A |
| Abstract |
Tango1 enables ER-to-Golgi trafficking of large proteins. We show here that loss of Tango1, in addition to disrupting protein secretion and ER/Golgi morphology, causes ER stress and defects in cell shape. We find that the previously observed dependence of smaller cargos on Tango1 is a secondary effect. If large cargos like Dumpy, which we identify as a Tango1 cargo, are removed from the cell, nonbulky proteins reenter the secretory pathway. Removal of blocking cargo also restores cell morphology and attenuates the ER-stress response. Thus, failures in the secretion of nonbulky proteins, ER stress, and defective cell morphology are secondary consequences of bulky cargo retention. By contrast, ER/Golgi defects in Tango1-depleted cells persist in the absence of bulky cargo, showing that they are due to a secretion-independent function of Tango1. Therefore, maintenance of ER/Golgi architecture and bulky cargo transport are the primary functions for Tango1. |
| 巻・号 | 114(48) |
| ページ | E10389-E10398 |
| 公開日 | 2017-11-28 |
| DOI | 10.1073/pnas.1711408114 |
| PII | 1711408114 |
| PMID | 29138315 |
| PMC | PMC5715762 |
| MeSH | Animals Aryl Hydrocarbon Receptor Nuclear Translocator / physiology* Drosophila Proteins / physiology* Drosophila melanogaster Endoplasmic Reticulum / physiology* Endoplasmic Reticulum Stress / physiology Gene Knockdown Techniques Golgi Apparatus / physiology* Mutagenesis Protein Transport / physiology Vesicular Transport Proteins / physiology* |
| IF | 9.412 |
| 引用数 | 15 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 16 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | 11098R-3 16858R-1 |