論文 - 詳細
| RRC ID | 49657 |
|---|---|
| 著者 | Chou MY, Amo R, Kinoshita M, Cherng BW, Shimazaki H, Agetsuma M, Shiraki T, Aoki T, Takahoko M, Yamazaki M, Higashijima S, Okamoto H. |
| タイトル | Social conflict resolution regulated by two dorsal habenular subregions in zebrafish. |
| ジャーナル | Science |
| Abstract |
When animals encounter conflict they initiate and escalate aggression to establish and maintain a social hierarchy. The neural mechanisms by which animals resolve fighting behaviors to determine such social hierarchies remain unknown. We identified two subregions of the dorsal habenula (dHb) in zebrafish that antagonistically regulate the outcome of conflict. The losing experience reduced neural transmission in the lateral subregion of dHb (dHbL)-dorsal/intermediate interpeduncular nucleus (d/iIPN) circuit. Silencing of the dHbL or medial subregion of dHb (dHbM) caused a stronger predisposition to lose or win a fight, respectively. These results demonstrate that the dHbL and dHbM comprise a dual control system for conflict resolution of social aggression. |
| 巻・号 | 352(6281) |
| ページ | 87-90 |
| 公開日 | 2016-4-1 |
| DOI | 10.1126/science.aac9508 |
| PII | 352/6281/87 |
| PMID | 27034372 |
| MeSH | Aggression / physiology* Animals Conflict, Psychological* Habenula / physiology* Hierarchy, Social Interpeduncular Nucleus / physiology Negotiating* Synaptic Transmission Zebrafish |
| IF | 41.846 |
| 引用数 | 66 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 41 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ゼブラフィッシュ | Tg(vglut2a:loxP-DsRed-loxP-GFP) Tg(narp:GAL4VP16) Tg (brn3a-hsp70:GFP ) Tg(gpr151:GAL4VP16) Tg(brn3a-hsp70:GFP-Cre) Tg(UAS:loxP-DsRed-loxP-GFP-TeNT) Tg(UAS: TeNT) Tg (UAS:GFP-TeNT) |