RRC ID 49657
著者 Chou MY, Amo R, Kinoshita M, Cherng BW, Shimazaki H, Agetsuma M, Shiraki T, Aoki T, Takahoko M, Yamazaki M, Higashijima S, Okamoto H.
タイトル Social conflict resolution regulated by two dorsal habenular subregions in zebrafish.
ジャーナル Science
Abstract When animals encounter conflict they initiate and escalate aggression to establish and maintain a social hierarchy. The neural mechanisms by which animals resolve fighting behaviors to determine such social hierarchies remain unknown. We identified two subregions of the dorsal habenula (dHb) in zebrafish that antagonistically regulate the outcome of conflict. The losing experience reduced neural transmission in the lateral subregion of dHb (dHbL)-dorsal/intermediate interpeduncular nucleus (d/iIPN) circuit. Silencing of the dHbL or medial subregion of dHb (dHbM) caused a stronger predisposition to lose or win a fight, respectively. These results demonstrate that the dHbL and dHbM comprise a dual control system for conflict resolution of social aggression.
巻・号 352(6281)
ページ 87-90
公開日 2016-4-1
DOI 10.1126/science.aac9508
PII 352/6281/87
PMID 27034372
MeSH Aggression / physiology* Animals Conflict, Psychological* Habenula / physiology* Hierarchy, Social Interpeduncular Nucleus / physiology Negotiating* Synaptic Transmission Zebrafish
IF 41.846
引用数 66
リソース情報
ゼブラフィッシュ Tg(vglut2a:loxP-DsRed-loxP-GFP) Tg(narp:GAL4VP16) Tg (brn3a-hsp70:GFP ) Tg(gpr151:GAL4VP16) Tg(brn3a-hsp70:GFP-Cre) Tg(UAS:loxP-DsRed-loxP-GFP-TeNT) Tg(UAS: TeNT) Tg (UAS:GFP-TeNT)