論文 - 詳細
| RRC ID | 49699 |
|---|---|
| 著者 | Cayuso J, Dzementsei A, Fischer JC, Karemore G, Caviglia S, Bartholdson J, Wright GJ, Ober EA. |
| タイトル | EphrinB1/EphB3b Coordinate Bidirectional Epithelial-Mesenchymal Interactions Controlling Liver Morphogenesis and Laterality. |
| ジャーナル | Dev Cell |
| Abstract |
Positioning organs in the body often requires the movement of multiple tissues, yet the molecular and cellular mechanisms coordinating such movements are largely unknown. Here, we show that bidirectional signaling between EphrinB1 and EphB3b coordinates the movements of the hepatic endoderm and adjacent lateral plate mesoderm (LPM), resulting in asymmetric positioning of the zebrafish liver. EphrinB1 in hepatoblasts regulates directional migration and mediates interactions with the LPM, where EphB3b controls polarity and movement of the LPM. EphB3b in the LPM concomitantly repels hepatoblasts to move leftward into the liver bud. Cellular protrusions controlled by Eph/Ephrin signaling mediate hepatoblast motility and long-distance cell-cell contacts with the LPM beyond immediate tissue interfaces. Mechanistically, intracellular EphrinB1 domains mediate EphB3b-independent hepatoblast extension formation, while EpB3b interactions cause their destabilization. We propose that bidirectional short- and long-distance cell interactions between epithelial and mesenchyme-like tissues coordinate liver bud formation and laterality via cell repulsion. |
| 巻・号 | 39(3) |
| ページ | 316-328 |
| 公開日 | 2016-11-7 |
| DOI | 10.1016/j.devcel.2016.10.009 |
| PII | S1534-5807(16)30722-5 |
| PMID | 27825440 |
| PMC | PMC5107609 |
| MeSH | Animals Body Patterning Cell Movement Cell Shape Ephrin-B1 / metabolism* Ephrin-B3 / metabolism* Epithelium / embryology* Epithelium / metabolism Functional Laterality* Liver / embryology* Mesoderm / embryology* Mesoderm / metabolism Morphogenesis* Pseudopodia / metabolism Receptors, Eph Family / metabolism* Zebrafish / embryology Zebrafish / metabolism Zebrafish Proteins / metabolism* |
| IF | 10.092 |
| 引用数 | 19 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 29 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ゼブラフィッシュ | Tg(sox17:EGFP) |