論文 - 詳細
| RRC ID | 49710 |
|---|---|
| 著者 | Liu YC, Hale ME. |
| タイトル | Local Spinal Cord Circuits and Bilateral Mauthner Cell Activity Function Together to Drive Alternative Startle Behaviors. |
| ジャーナル | Curr Biol |
| Abstract |
The reticulospinal Mauthner cells (M-cells) of the startle circuit have been considered to be dedicated to one basic motor output and the C-type startle response in fish. The neural circuit underlying the C-start, a startle behavior in which the fish forms a "C"-shaped body bend has been described in depth in goldfish and zebrafish [1, 2] and is thought to occur in other species [3, 4]. However, previous research has shown that some species can perform a second type of startle called the S-start [5-7]. This startle response, in which the first movement creates an "S"-shaped body bend achieved with regional muscle activity on left and right sides, cannot be explained by M-cell circuit models. Here we use larval zebrafish to examine the S-start circuit. Since S-starts are elicited through tail stimulation [5-7] and ablating M-cells abolishes short-latency tail-elicited startles [8, 9], we hypothesized that M-cell activity was necessary for S-start generation. Our findings show that the M-cells fire simultaneously to generate the S-start. However, simultaneous M-cell spikes generated through direct current injection were not sufficient to generate S-starts. Through recordings of motoneurons, inhibitory interneurons, and sensory neurons, we uncover a mechanism for generating alternative startle behaviors; local sensory inputs drive inhibitory interneuron activity, which inhibits caudal motoneurons and pre-conditions their excitability prior to the arrival of M-cell spikes in the tail. We suggest that this motoneuron hyperpolarization can bias motor output to left or right sides, determining whether the fish performs a C-start or an S-start behavior. |
| 巻・号 | 27(5) |
| ページ | 697-704 |
| 公開日 | 2017-3-6 |
| DOI | 10.1016/j.cub.2017.01.019 |
| PII | S0960-9822(17)30019-2 |
| PMID | 28216316 |
| MeSH | Animals Interneurons / physiology* Motor Neurons / physiology* Neural Pathways / physiology Reflex, Startle / physiology* Sensory Receptor Cells / physiology* Spinal Cord / physiology* Zebrafish / physiology* |
| IF | 9.601 |
| 引用数 | 10 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ゼブラフィッシュ | Tol-056 |